European Journal of Oral Sciences, Volume 133, Issue 5, October 2025.Abstract Stem cells from the apical papilla (SCAP) are essential for regenerative endodontic treatment. Although mineral trioxide aggregate (MTA) and Biodentine are widely used in regenerative endodontic treatment procedures, their effects on SCAP remain unclear.
Olena Rakhimova +6 more
wiley +1 more source
Mechanistic insights into dental stem cells‐derived exosomes in regenerative endodontics
International Endodontic Journal, Volume 58, Issue 9, Page 1384-1407, September 2025.Abstract Background Dental pulp is a richly vascularised and innervated tissue vital for tooth vitality, sensory function, and structural integrity. While conventional root canal therapy effectively treats necrotic permanent teeth, it irreversibly eliminates pulp vitality, potentially increasing the risk of secondary infections and long‐term structural
Paras Ahmad +4 more
wiley +1 more source
Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro [PDF]
, 2015 The transcription factor Nuclear Factor I-C (NFIC) has been implicated in the regulation of tooth root development, where it may be anticipated to impact on the behavior of stem cells from the apical papilla (SCAPs) and root odontoblast activity.
Cooper, Paul +8 more
core +1 more source
To Assess the Cell Viability of Triple Antibiotic Paste under Confocal Microscope: An In Vitro Study [PDF]
Journal of South Asian Association of Pediatric DentistryBackground and aim: Regenerative endodontic procedures (REPs) rely on the viability of stem cells from the apical papilla (SCAPs) to promote tissue repair and regeneration in immature teeth.
Elanthendral Saravanan +1 more
doaj +1 more source
Secreted products of oral bacteria and biofilms impede mineralization of apical papilla stem cells in TLR-, species-, and culture-dependent fashion [PDF]
, 2018 Regenerative endodontics exploits the mineralization potential of stem cells from the apical papilla (SCAPs) in order to promote root maturation of permanent immature teeth.
Brinker, Marja G L +5 more
core +1 more source
The residual antibacterial effects of radiopaque double antibiotic paste after various treatment times [PDF]
, 2018 Indiana University-Purdue University Indianapolis (IUPUI)Introduction: Regenerative endodontic procedures require adequate disinfection of immature teeth with necrotic pulps. Regeneration endodontic procedures have been shown to increase width and length
Biggerstaff, Ross
core +1 more source
Scientific Reports, 2020 Engineered tissue constructs require the fabrication of highly perfusable and mature vascular networks for effective repair and regeneration. In tissue engineering, stem cells are widely employed to create mature vascularized tissues in vitro.
S. Prakash Parthiban +5 more
doaj +1 more source
Advances in Revascularization of Young Permanent Teeth [PDF]
, 2021 Treatment of immature permanent teeth with a necrotic pulp or an irreversible pulp inflammation have for long been limited to the creation of an apical calcified barrier to permit a correct apical seal thus arresting the tooth in its development stage.
Jamet, Jean-Hugues Abel René
core
Observations of Trends and Successes of Revascularization Therapy at Virginia Commonwealth University: A Retrospective Study [PDF]
, 2018 The aim of this study was to determine the trends in protocol, success rates, and consistency in follow up of revascularization procedures in a controlled environment.
Sedwick, Richard W
core +1 more source
Cytotoxicity of Various Endodontic Materials on Stem Cells of Human Apical Papilla [PDF]
, 2015 Introduction: This in vitro study assessed and compared the cytotoxicity of mineral trioxide aggregate (MTA), calcium-enriched mixture (CEM) cement, Biodentine (BD) and octacalcium phosphate (OCP) on stem cells of the human apical papilla (SCAP). Methods
Farhad Mollashahi, Narges +2 more
core +2 more sources