Results 141 to 150 of about 17,770 (172)

Conformation of sulfated galactan and sulfated fucan in aqueous solutions: Implications to their anticoagulant activities

Journal of Molecular Graphics and Modelling, 2007
The discovery of sulfated galactans and sulfated fucans in marine invertebrates with simple and ordered structures opened new perspectives to investigate the biological activity of these molecules and to determine whether different structures confer high affinity for a particular protein. We undertook a conformational analysis of a 2-sulfated, 3-linked
Camila F, Becker, Jorge A, Guimarães, Paulo A S, Mourão, Hugo, Verli   +3 more
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Water Soluble Sulfated-Fucans With Immune-Enhancing Properties From Ecklonia cava

International Journal of Biological Macromolecules, 2014
Water-soluble sulfated fucans isolated from Ecklonia cava were fractionated using an anion-exchange chromatography to investigate their molecular characteristics and immunomodulating activities. The crude fucoidan extract and purified fractions (EF1, EF2, and EF3) consisted mostly of different ratios of neutral sugars, proteins, sulfates, uronic acids,
SangGuan You
exaly   +3 more sources

Searching for Alternatives to Heparin Sulfated Fucans from Marine Invertebrates

Trends in Cardiovascular Medicine, 1999
We describe a variety of sulfated polysaccharides with regular and well-defined structures which are useful tools for elucidating structure/biological function relationship. Several of these compounds have anticoagulant and antithrombotic activities.
P A, Mourão, M S, Pereira
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In vitro and in vivo immunoregulatory activity of sulfated fucan from the sea cucumber A. leucoprocta

International Journal of Biological Macromolecules, 2021
The in vitro and in vivo immunoregulatory activity of a water-soluble sulfated fucan AL1-1 from the sea cucumber A. leucoprocta was elucidated. In vitro experiments showed that AL1-1 up-regulated immunostimulatory activities in RAW264.7 cells and that it could successfully promote ROS production and phagocytic activity, increase secretion levels of ...
Guo, Feng, Su, Laijin, Shen, Chen, Wang, Teng, Zhou, Dejian, Chen, Yin, Guo, Shoudong   +6 more
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Inhibition of Complement Activation by Natural Sulfated Polysaccharides (Fucans) From Brown Seaweed

Molecular Immunology, 1994
In the present study, we demonstrate that natural sulfated polysaccharides (fucans) isolated from brown seaweed are potent inhibitors of human complement activation. A fucan fraction of chromatographic molecular weight 22,600, termed BS8, was found to inhibit classical and alternative pathway activation in whole serum in a dose-dependent fashion. Fucan
Evelyne Fischer, Catherine Boisson-Vidal, M D Kazatchkine   +2 more
exaly   +3 more sources

Antithrombin activity of a fucan sulfate from the brown seaweed Ecklonia kurome

Thrombosis Research, 1991
The mechanism of antithrombin action of a fucan sulfate (C-II), which was isolated from the brown seaweed Ecklonia kurome, was examined by clotting method using a thrombin-fibrinogen system and by amidolytic method using a chromogenic substrate in the presence and the absence of antithrombin III (AT III) or heparin cofactor II (HC II).
T, Nishino, Y, Aizu, T, Nagumo
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Structure and anticoagulant activity of a sulfated fucan from the sea cucumber Acaudina leucoprocta

International Journal of Biological Macromolecules, 2020
A sulfated fucan was extracted, purified, and characterized from Acaudina leucoprocta (a low value sea cucumber) to better understand and utilize this species. The structure of the sulfated fucan was elucidated using chemical and modern spectroscopic analyses including HPGPC, IR, AFM, GC-MS, and NMR, and its bioactivity was investigated.
Wentao, He, Haihong, Sun, Laijin, Su, Dejian, Zhou, Xing, Zhang, Deng, Shanggui, Yin, Chen   +6 more
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A highly regular fucan sulfate from the sea cucumber Stichopus horrens

Carbohydrate Research, 2018
A highly regular fucan sulfate SHFS was isolated from the sea cucumber Stichopus horrens by extraction of the body walls in the presence of papain followed by ion-exchange and gel permeation chromatography. SHFS had MW of about 140 kDa and contained fucose and sulfate in the molar ratio of about 1:1.
Nadezhda E, Ustyuzhanina, Maria I, Bilan, Andrey S, Dmitrenok, Elizaveta Yu, Borodina, Nikolay E, Nifantiev, Anatolii I, Usov   +5 more
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Mild Acid Hydrolysis of Sulfated Fucans: A Selective 2-Desulfation Reaction and an Alternative Approach for Preparing Tailored Sulfated Oligosaccharides. [PDF]

Glycobiology, 2005
Sulfated fucans from marine invertebrates have simple, linear structures, composed of repeating units of oligosaccharides. Most of these polysaccharides contain 3-linked fucosyl units, but each species of invertebrate has a specific pattern of sulfation.
Paulo A.S. Mourão, Ana Paula Valente, Vitor H Pomin   +2 more
exaly   +3 more sources

A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity

Carbohydrate Polymers, 2021
Marine sulfated polysaccharides have aroused widespread concern for their various structures and bioactivities. Peroxide depolymerization is a common strategy in analysis of structures and structure-activity relationships of polysaccharides. However, confirming the depolymerization process and exact structures of the degradation products is still a ...
Xiaomei, Li, Shanni, Li, Jie, Liu, Lisha, Lin, Huifang, Sun, Wenjiao, Yang, Ying, Cai, Na, Gao, Lutan, Zhou, Hongbo, Qin, Ronghua, Yin, Jinhua, Zhao   +11 more
openaire   +2 more sources