Results 21 to 30 of about 53,984 (298)
Membrane Curvature in Synaptic Vesicle Fusion and Beyond [PDF]
Cell, 2010 Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.
McMahon, Harvey +2 more
openaire +3 more sources
Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release
Cell Reports, 2019 Summary: SNARE-mediated synaptic vesicle (SV) fusion is controlled by multiple regulatory proteins that determine neurotransmitter release efficiency.
Francisco José López-Murcia +4 more
doaj +1 more source
Advanced Science, 2023 Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorly ...
Houda Yasmine Ali Moussa +6 more
doaj +1 more source
F1000Research, 2017 Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
doaj +1 more source
Ca<sup>2+</sup>-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition. [PDF]
Trends Cell Biol, 2018 Recent structural and functional studies of the synaptic vesicle fusion machinery suggest an inhibited tripartite complex consisting of neuronal soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs), synaptotagmin, and complexin prior to Ca2+-triggered synaptic vesicle fusion.
Brunger AT +4 more
europepmc +4 more sources
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]
, 2016 Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio +15 more
core +5 more sources
Nitric Oxide Modulates Synaptic Vesicle Docking/Fusion Reactions [PDF]
Neuron, 1996 Nitric oxide (NO) stimulates calcium-independent neurotransmitter release from synaptosomes. NO-stimulated release was found to be inhibited by Botulinum neurotoxins that inactivate the core complex of synaptic proteins involved in the docking and fusion of synaptic vesicles.
Meffert, Mollie K +3 more
openaire +2 more sources
Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. [PDF]
, 2015 Disrupting particular mitochondrial fission and fusion proteins leads to the death of specific neuronal populations; however, the normal functions of mitochondrial fission in neurons are poorly understood, especially in vivo, which limits the ...
Berthet, A +12 more
core +6 more sources
Fusion of Endosomes Involved in Synaptic Vesicle Recycling [PDF]
Molecular Biology of the Cell, 1999 Recycling of vesicles of the regulated secretory pathway presumably involves passage through an early endosomal compartment as an intermediate step. To learn more about the involvement of endosomes in the recycling of synaptic and secretory vesicles we studied in vitro fusion of early endosomes derived from pheochromocytoma (PC12) cells. Fusion was not
Holroyd, C. +3 more
openaire +3 more sources
Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release [PDF]
, 2014 Synaptotagmin 1 (Syt1) is a synaptic vesicle integral membrane protein that regulates neurotransmitter release by activating fast synchronous fusion and suppressing slower asynchronous release.
Lee, Jihye, Littleton, J. Troy
core +1 more source