Results 31 to 40 of about 53,467 (282)

Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species

Cells, 2023
The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control ...
Astrid G. Petzoldt
doaj   +1 more source

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking

Frontiers in Neuroscience, 2021
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell, Audrey T. Medeiros, John B. Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R. Morgan   +5 more
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Quantitative Analysis Linking Inner Hair Cell Voltage Changes and Postsynaptic Conductance Change: A Modelling Study [PDF]

, 2015
This paper presents a computational model which estimates the postsynaptic conductance change of mammalian Type I afferent peripheral process when airborne acoustic waves impact on the tympanic membrane. A model of the human auditory periphery is used to
Drakakis, EM, Prokopiou, AN
core   +3 more sources

Synaptic vesicle fusion: today and beyond

Nature Structural & Molecular Biology, 2019
Researchers working on synaptic vesicle fusion and neurotransmitter release share their views on the most interesting developments in their field and the challenges that lie ahead.
Brose, N. ; https://orcid.org/0000-0003-0938-8534, Brunger, A., Cafiso, D., Chapman, E., Diao, J., Hughson, F., Jackson, M., Jahn, R., Lindau, M., Ma, C., Rizo, J., Shin, Y., Söllner, T., Tamm, L., Yoon, T., Zhang, Y.   +15 more
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Snapin Facilitates the Synchronization of Synaptic Vesicle Fusion [PDF]

Neuron, 2009
Synaptic vesicle (SV) fusion is a fine-tuned process requiring a concert of fusion machineries. Using cortical neurons from snapin-deficient mice, we reveal a role for Snapin in facilitating synchronous release. In addition to reduced frequency of miniature excitatory postsynaptic currents (mini-EPSCs) and smaller release-ready vesicle pool (RRP) size,
Pan, Ping-Yue, Tian, Jin-Hua, Sheng, Zu-Hang   +2 more
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Cortical granule exocytosis is mediated by alpha-SNAP and N-Ethilmaleimide sensitive factor in mouse eggs [PDF]

, 2015
Cortical granule exocytosis (CGE), also known as cortical reaction, is a calciumregulated secretion that represents a membrane fusion process during meiotic cell division of eggs.
Bello, Oscar Daniel, de Paola, Maria Matilde, Michaut, Marcela Alejandra   +2 more
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Synaptic Vesicles Position Complexin to Block Spontaneous Fusion [PDF]

Neuron, 2013
Synapses continually replenish their synaptic vesicle (SV) pools while suppressing spontaneous fusion events, thus maintaining a high dynamic range in response to physiological stimuli. The presynaptic protein complexin can both promote and inhibit fusion through interactions between its α-helical domain and the SNARE complex.
Wragg, Rachel T., Snead, David, Dong, Yongming, Ramlall, Trudy F., Menon, Indu, Bai, Jihong, Eliezer, David, Dittman, Jeremy S.   +7 more
openaire   +2 more sources

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

eLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen   +12 more
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Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

eLife, 2015
The energy required to fuse synaptic vesicles with the plasma membrane (‘activation energy’) is considered a major determinant in synaptic efficacy. From reaction rate theory, we predict that a class of modulations exists, which utilize linear modulation
Sebastiaan Schotten, Marieke Meijer, Alexander Matthias Walter, Vincent Huson, Lauren Mamer, Lawrence Kalogreades, Mirelle ter Veer, Marvin Ruiter, Nils Brose, Christian Rosenmund, Jakob Balslev Sørensen, Matthijs Verhage, Lennart Niels Cornelisse   +12 more
doaj   +1 more source