Results 21 to 30 of about 53,467 (282)

Palmitoylation of the synaptic vesicle fusion machinery [PDF]

Journal of Neurochemistry, 2009
AbstractThe fusion of synaptic vesicles with the pre‐synaptic plasma membrane mediates the secretion of neurotransmitters at nerve terminals. This pathway is regulated by an array of protein–protein interactions. Of central importance are the soluble NSF (N‐ethylmaleimide‐sensitive factor) attachment protein receptor (SNARE) proteins syntaxin 1 and ...
Prescott, Gerald R, Gorleku, Oforiwa A, Greaves, Jennifer, Chamberlain, Luke H   +3 more
openaire   +3 more sources

Ultrastructural and functional fate of recycled vesicles in hippocampal synapses [PDF]

, 2015
Efficient recycling of synaptic vesicles is thought to be critical for sustained information transfer at central terminals. However, the specific contribution that retrieved vesicles make to future transmission events remains unclear.
A Denker, A Denker, A Denker, A Ratnayaka, A Ratnayaka, AA Alabi, AW Henkel, AW Henkel, B Granseth, C Rosenmund, D Kamin, DM Ramirez, EA Lemke, FE Schweizer, G Miesenbock, H Park, J Raingo, JL Pyle, K Staras, KJ Darcy, KJ Darcy, M Bal, M Ertunc, M Frerking, MA Colicos, MA Gaffield, MW Fowler, N Harata, O Shupliakov, RP de Lange, S Sankaranarayanan, S Sankaranarayanan, S Tsuriel, S Watanabe, S Watanabe, SO Rizzoli, SO Rizzoli, SS Zakharenko, T Schikorski, T Schikorski, TA Ryan, TA Ryan, TC Sudhof, V Marra, V Marra, V Westphal, WJ Betz, Y Hua, Y Sara, Y Zhu, Z Hua, Z Li   +51 more
core   +5 more sources

Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release

Cell Reports, 2019
Summary: SNARE-mediated synaptic vesicle (SV) fusion is controlled by multiple regulatory proteins that determine neurotransmitter release efficiency.
Francisco José López-Murcia, Kerstin Reim, Olaf Jahn, Holger Taschenberger, Nils Brose   +4 more
doaj   +1 more source

Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending

Advanced Science, 2023
Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorly ...
Houda Yasmine Ali Moussa, Kyung Chul Shin, Janarthanan Ponraj, Soo Jin Kim, Je‐Kyung Ryu, Said Mansour, Yongsoo Park   +6 more
doaj   +1 more source

How do you recognize and reconstitute a synaptic vesicle after fusion? [version 1; referees: 3 approved]

F1000Research, 2017
Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
doaj   +1 more source

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]

, 2016
Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio, Belluzzi, Elisa, Beltramini, Mariano, Bubacco, Luigi, Carrion, Maria Per\ue8z, Cirnaru, Maria Daniela, Civiero, Laura, Cogo, Susanna, Franchin, Cinzia, Gonnelli, Adriano, Greggio, Elisa, Marte, Antonella, Onofri, Franco, Piccoli, Giovanni, Plotegher, Nicoletta, Russo, Isabella   +15 more
core   +5 more sources

Nitric Oxide Modulates Synaptic Vesicle Docking/Fusion Reactions [PDF]

Neuron, 1996
Nitric oxide (NO) stimulates calcium-independent neurotransmitter release from synaptosomes. NO-stimulated release was found to be inhibited by Botulinum neurotoxins that inactivate the core complex of synaptic proteins involved in the docking and fusion of synaptic vesicles.
Meffert, Mollie K, Calakos, Nicole C, Scheller, Richard H, Schulman, Howard   +3 more
openaire   +2 more sources

Fusion of Endosomes Involved in Synaptic Vesicle Recycling [PDF]

Molecular Biology of the Cell, 1999
Recycling of vesicles of the regulated secretory pathway presumably involves passage through an early endosomal compartment as an intermediate step. To learn more about the involvement of endosomes in the recycling of synaptic and secretory vesicles we studied in vitro fusion of early endosomes derived from pheochromocytoma (PC12) cells. Fusion was not
Holroyd, C., Kistner, U., Annaert, W., Jahn, R.   +3 more
openaire   +3 more sources

Ca²⁺-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition. [PDF]

Trends Cell Biol, 2018
Recent structural and functional studies of the synaptic vesicle fusion machinery suggest an inhibited tripartite complex consisting of neuronal soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs), synaptotagmin, and complexin prior to Ca2+-triggered synaptic vesicle fusion.
Brunger AT, Leitz J, Zhou Q, Choi UB, Lai Y.   +4 more
europepmc   +4 more sources

Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]

, 2017
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván, Cano, Raquel, Groisman, Ayelén Ivana, Mazzone, Graciela Luján, Tabares, Lucía, Uchitel, Osvaldo Daniel   +5 more
core   +1 more source