Results 11 to 20 of about 53,467 (282)
Membrane Curvature in Synaptic Vesicle Fusion and Beyond [PDF]
Cell, 2010 Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.
McMahon, Harvey +2 more
openaire +5 more sources
Compound vesicle fusion increases quantal size and potentiates synaptic transmission [PDF]
Nature, 2009 Exocytosis at synapses involves fusion between vesicles and the plasma membrane. Although compound fusion between vesicles was proposed to occur at ribbon-type synapses, whether it exists, how it is mediated, and what role it plays at conventional synapses remain unclear.
Liming, He +7 more
openaire +4 more sources
SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling. [PDF]
Front Mol Neurosci, 2021 Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. SNARE proteins embedded in opposing membranes spontaneously assemble to drive membrane fusion and cargo exchange in vitro.
Sauvola CW, Littleton JT.
europepmc +5 more sources
Cell ReportsSummary: Efficient synaptic vesicle (SV) recycling is essential for sustaining synaptic transmission. While the multiple roles of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in SV recycling are well documented, presynaptic regulation of ...
Tomofumi Yoshida +7 more
doaj +3 more sources
Molecular Dynamics Simulations of the Proteins Regulating Synaptic Vesicle Fusion. [PDF]
Membranes (Basel), 2023 Neuronal transmitters are packaged in synaptic vesicles (SVs) and released by the fusion of SVs with the presynaptic membrane (PM). An inflow of Ca2+ into the nerve terminal triggers fusion, and the SV-associated protein Synaptotagmin 1 (Syt1) serves as a Ca2+ sensor. In preparation for fusion, SVs become attached to the PM by the SNARE protein complex,
Bykhovskaia M.
europepmc +4 more sources
Disorders of synaptic vesicle fusion machinery [PDF]
Journal of Neurochemistry, 2020 AbstractThe revolution in genetic technology has ushered in a new age for our understanding of the underlying causes of neurodevelopmental, neuromuscular and neurodegenerative disorders, revealing that the presynaptic machinery governing synaptic vesicle fusion is compromised in many of these neurological disorders. This builds upon decades of research
Holly Melland +2 more
openaire +3 more sources
Nature Structural & Molecular Biology, 2008 The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion.
Josep, Rizo, Christian, Rosenmund
openaire +2 more sources
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin. [PDF]
Nat Commun, 2019 Courtney NA +3 more
europepmc +2 more sources
Synaptic Vesicle Fusion without SNARE Transmembrane Regions [PDF]
Developmental Cell, 2013 Diverse roles in membrane fusion have been proposed for the transmembrane regions (TMRs) of SNARE proteins, including formation of channel-like transmembrane pores. Reporting in Neuron, Zhou et al. (2013) show that lipid-anchored SNAREs lacking TMRs can support neurotransmitter release, suggesting that SNAREs function primarily as power engines that ...
Rizo, Josep, Xu, Junjie
openaire +2 more sources
Research progress on vesicle cycle and neurological disorders
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Neurons are special polarized cells whose synaptic vesicles release neurotransmitters into the synaptic cleft, acting on postsynaptic receptors and thus transmitting information from presynaptic to postsynaptic states.
Chengcheng Zhang, Li-Juan Zhu, Ce Chen
doaj +1 more source