Results 51 to 60 of about 53,467 (282)

Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
Amaral, Assaf, Bayer, Bergmann, Bergmann, Betz, Blackstad, Blasi, Bliss, Cameron, Crawford, D. Grabs, Dyck, Feany, Frotscher, Fykse, Haug, Hollmann, Howell, Hsu, Jahn, Jahn, Johnston, Johnston, Knaus, Laemmli, Lah, Lahr, Linstedt, Linstedt, M. Bergmann, M. Brich, M. Gratzl, Marquèze-Pouey, Mundigl, O'Connor, Ovtscharoff, Oyler, P. A. Fox, Règnier-Vigouroux, Scarfone, Schiavo, Schilling, Schmied, Slomianka, Sloviter, Söllner, Th. Schuster, Thomas, Towbin, Westbrook, Zimmer   +51 more
core   +1 more source

Optical detection of three modes of endocytosis at hippocampal synapses

eLife, 2018
Coupling of synaptic vesicle fusion and retrieval constitutes a core mechanism ensuring maintenance of presynaptic function. Recent studies using fast-freeze electron microscopy and capacitance measurements reported an ultrafast mode of endocytosis ...
Natali L Chanaday, Ege T Kavalali
doaj   +1 more source

Tracking the dynamics of single fused synaptic vesicle proteins from a single ribbon active zone in zebrafish retinal bipolar cells

STAR Protocols, 2022
Summary: Clearance of fused synaptic vesicle components and availability of release sites are important determinants of recovery from short-term synaptic depression. However, the dynamics of release site clearance are not well established.
Abhishek P. Shrestha, Thirumalini Vaithianathan   +1 more
doaj   +1 more source

Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1

FEBS Open Bio, 2022
Neurotransmitter release by Ca2+‐triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N‐ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin‐1, SNAP‐25, and ...
Shen Wang, Cong Ma
doaj   +1 more source

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

eLife, 2022
Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane, which leads to neurotransmitter release. This exocytosis is triggered by brief and local elevations of intracellular Ca2+ with remarkably high sensitivity.
Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob B Sørensen, Alexander M Walter   +4 more
doaj   +1 more source

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]

, 1981
Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
core   +2 more sources

Molecular correlates of synaptic vesicle docking and fusion

Current Opinion in Neurobiology, 1994
The mechanisms responsible for neurotransmitter release at the synapse have been extensively studied using biochemical, genetic, and cell biological approaches. Several significant advances have recently contributed towards an improved understanding of the molecular details of both synaptic vesicle docking and fusion, and of the general process of ...
M K, Bennett, R H, Scheller
openaire   +2 more sources

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion

eLife, 2017
The synaptic vesicle Ca2+ sensor Synaptotagmin binds Ca2+ through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated.
Zhuo Guan, Maria Bykhovskaia, Ramon A Jorquera, Roger Bryan Sutton, Yulia Akbergenova, J Troy Littleton   +5 more
doaj   +1 more source

γ-synuclein is a novel player in the control of body lipid metabolism [PDF]

, 2013
Peer reviewedPublisher ...
Buchman, Vladimir L, Millership, Steven, Ninkina, Natalia, Rochford, Justin J   +3 more
core   +1 more source

Beyond the MUN domain, Munc13 controls priming and depriming of synaptic vesicles

Cell Reports
Summary: Synaptic vesicle docking and priming are dynamic processes. At the molecular level, SNAREs (soluble NSF attachment protein receptors), synaptotagmins, and other factors are critical for Ca2+-triggered vesicle exocytosis, while disassembly ...
Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, John Jacob Peters, Sergio Couoh-Cardel, Austin L. Wang, Axel T. Brunger   +7 more
doaj   +1 more source