Results 61 to 70 of about 53,467 (282)
Mass spectrometry uncovers intermediates and off-pathway complexes for SNARE complex assembly
Communications Biology, 2023 Chemical cross-linking and native mass spectrometry aid the thorough investigation of complex formation and multimerisation of synaptic vesicle fusion-mediating SNARE complex, including the role of complexin-1 in its assembly.
Julia Hesselbarth, Carla Schmidt
doaj +1 more source
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.
, 2019 Regulated exocytosis of synaptic vesicles is substantially faster than of endocrine dense core vesicles despite similar molecular machineries. The reasons for this difference are unknown and could be due to different regulatory proteins, different ...
Castle, J. +10 more
core +1 more source
The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]
, 2016 Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E +7 more
core +1 more source
The fate of synaptic vesicle components upon fusion
Communicative & Integrative Biology, 2010 Neurotransmitter release relies on the fusion of synaptic vesicles with the plasma membrane of synaptic boutons, which is followed by the recycling of vesicle components and formation of new vesicles. It is not yet clear whether upon fusion the vesicles persist as multimolecular patches in the plasma membrane, or whether they segregate into individual ...
Opazo, Felipe, Rizzoli, S. O.
openaire +3 more sources
Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses
Cell Reports, 2019 Summary: At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by ...
Marta Orlando +3 more
doaj +1 more source
α-Synuclein-induced deformation of small unilamellar vesicles
QRB Discovery, 2022 α-Synuclein is a small neuronal protein that reversibly associates with lipid membranes. The membrane interactions are believed to be central to the healthy function of this protein involved in synaptic plasticity and neurotransmitter release.
Katarzyna Makasewicz +3 more
doaj +1 more source
Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies [PDF]
, 2012 The auditory system processes time and intensity through separate brainstem pathways to derive spatial location as well as other salient features of sound.
Goutman, Juan Diego
core +1 more source
Regulation of plasma membrane expansion during axon formation [PDF]
, 2018 Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano +2 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
eLife, 2013 α-Synuclein is a presynaptic protein that is implicated in Parkinson's and other neurodegenerative diseases. Physiologically, native α-synuclein promotes presynaptic SNARE-complex assembly, but its molecular mechanism of action remains unknown.
Jiajie Diao +7 more
doaj +1 more source