Results 31 to 40 of about 53,984 (298)

Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species

Cells, 2023
The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control ...
Astrid G. Petzoldt
doaj   +1 more source

Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]

, 2017
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván, Cano, Raquel, Groisman, Ayelén Ivana, Mazzone, Graciela Luján, Tabares, Lucía, Uchitel, Osvaldo Daniel   +5 more
core   +1 more source

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking

Frontiers in Neuroscience, 2021
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell, Audrey T. Medeiros, John B. Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R. Morgan   +5 more
doaj   +1 more source

Quantitative Analysis Linking Inner Hair Cell Voltage Changes and Postsynaptic Conductance Change: A Modelling Study [PDF]

, 2015
This paper presents a computational model which estimates the postsynaptic conductance change of mammalian Type I afferent peripheral process when airborne acoustic waves impact on the tympanic membrane. A model of the human auditory periphery is used to
Drakakis, EM, Prokopiou, AN
core   +3 more sources

Synaptic vesicle fusion: today and beyond

Nature Structural & Molecular Biology, 2019
Researchers working on synaptic vesicle fusion and neurotransmitter release share their views on the most interesting developments in their field and the challenges that lie ahead.
Brose, N. ; https://orcid.org/0000-0003-0938-8534, Brunger, A., Cafiso, D., Chapman, E., Diao, J., Hughson, F., Jackson, M., Jahn, R., Lindau, M., Ma, C., Rizo, J., Shin, Y., Söllner, T., Tamm, L., Yoon, T., Zhang, Y.   +15 more
openaire   +4 more sources

Snapin Facilitates the Synchronization of Synaptic Vesicle Fusion [PDF]

Neuron, 2009
Synaptic vesicle (SV) fusion is a fine-tuned process requiring a concert of fusion machineries. Using cortical neurons from snapin-deficient mice, we reveal a role for Snapin in facilitating synchronous release. In addition to reduced frequency of miniature excitatory postsynaptic currents (mini-EPSCs) and smaller release-ready vesicle pool (RRP) size,
Pan, Ping-Yue, Tian, Jin-Hua, Sheng, Zu-Hang   +2 more
openaire   +2 more sources

Synaptic Vesicles Position Complexin to Block Spontaneous Fusion [PDF]

Neuron, 2013
Synapses continually replenish their synaptic vesicle (SV) pools while suppressing spontaneous fusion events, thus maintaining a high dynamic range in response to physiological stimuli. The presynaptic protein complexin can both promote and inhibit fusion through interactions between its α-helical domain and the SNARE complex.
Wragg, Rachel T., Snead, David, Dong, Yongming, Ramlall, Trudy F., Menon, Indu, Bai, Jihong, Eliezer, David, Dittman, Jeremy S.   +7 more
openaire   +2 more sources

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

eLife, 2020
Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan, Manindra Bera, Jeff Coleman, James E Rothman, Shyam S Krishnakumar   +4 more
doaj   +1 more source

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

eLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen   +12 more
doaj   +1 more source

Dual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion. [PDF]

Biomolecules
During neurotransmission, neurotransmitters are released less than a millisecond after the arrival of the action potential. To achieve this ultra-fast event, the synaptic vesicle must be pre-docked to the plasma membrane. In this primed state, SNAREpins, the protein-coiled coils whose assembly provides the energy to trigger fusion, are partly zippered ...
Caruel M, Pincet F.
europepmc   +4 more sources