Results 41 to 50 of about 53,984 (298)

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

eLife, 2015
The energy required to fuse synaptic vesicles with the plasma membrane (‘activation energy’) is considered a major determinant in synaptic efficacy. From reaction rate theory, we predict that a class of modulations exists, which utilize linear modulation
Sebastiaan Schotten, Marieke Meijer, Alexander Matthias Walter, Vincent Huson, Lauren Mamer, Lawrence Kalogreades, Mirelle ter Veer, Marvin Ruiter, Nils Brose, Christian Rosenmund, Jakob Balslev Sørensen, Matthijs Verhage, Lennart Niels Cornelisse   +12 more
doaj   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion [PDF]

Science, 2008
During synaptic vesicle fusion, the soluble N -ethylmaleimide-sensitive factor–attachment protein receptor (SNARE) protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a “closed” conformation outside the SNARE complex and an “open” conformation in the SNARE complex ...
Stefan H, Gerber, Jong-Cheol, Rah, Sang-Won, Min, Xinran, Liu, Heidi, de Wit, Irina, Dulubova, Alexander C, Meyer, Josep, Rizo, Marife, Arancillo, Robert E, Hammer, Matthijs, Verhage, Christian, Rosenmund, Thomas C, Südhof   +12 more
openaire   +5 more sources

Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft

Frontiers in Synaptic Neuroscience, 2010
Glutamate is released from synaptic vesicles following formation of a fusion pore, connecting the vesicle interior with the synaptic cleft. Release is proposed to result from either full fusion of the vesicle with the terminal membrane or by ‘kiss-
Jon T Brown, Kate L Weatherall, Laura R Corria, Thomas E Chater, John Isaac, Neil V Marrion   +5 more
doaj   +1 more source

Activity-dependence of synaptic vesicle dynamics [PDF]

, 2017
The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling.
Forte, Luca A, Gramlich, Michael W, Klyachko, Vitaly A   +2 more
core   +2 more sources

Reconstituting Basic Steps of Synaptic Vesicle Fusion [PDF]

Biophysical Journal, 2013
Neurotransmitter release depends critically on: the SNAREs syntaxin-1, synaptobrevin and SNAP-25, which form SNARE complexes that bridge the vesicle and plasma membranes; NSF/SNAPs, which disassemble SNARE complexes; Munc18-1, which binds to syntaxin-1 and, together with Munc13, orchestrates SNARE-complex assembly; and the Ca2+ sensor synaptotagmin-1 ...
Ma, Cong, Su, Lijing, Seven, Alpay B., Xu, Yibin, Rizo, Josep   +4 more
openaire   +1 more source

Tracking the dynamics of single fused synaptic vesicle proteins from a single ribbon active zone in zebrafish retinal bipolar cells

STAR Protocols, 2022
Summary: Clearance of fused synaptic vesicle components and availability of release sites are important determinants of recovery from short-term synaptic depression. However, the dynamics of release site clearance are not well established.
Abhishek P. Shrestha, Thirumalini Vaithianathan   +1 more
doaj   +1 more source

Optical detection of three modes of endocytosis at hippocampal synapses

eLife, 2018
Coupling of synaptic vesicle fusion and retrieval constitutes a core mechanism ensuring maintenance of presynaptic function. Recent studies using fast-freeze electron microscopy and capacitance measurements reported an ultrafast mode of endocytosis ...
Natali L Chanaday, Ege T Kavalali
doaj   +1 more source

Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1

FEBS Open Bio, 2022
Neurotransmitter release by Ca2+‐triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N‐ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin‐1, SNAP‐25, and ...
Shen Wang, Cong Ma
doaj   +1 more source