Results 1 to 10 of about 38,857 (196)
Electrostatic regulation of the cis- and trans-membrane interactions of synaptotagmin-1
Scientific Reports, 2022 Synaptotagmin-1 is a vesicular protein and Ca2+ sensor for Ca2+-dependent exocytosis. Ca2+ induces synaptotagmin-1 binding to its own vesicle membrane, called the cis-interaction, thus preventing the trans-interaction of synaptotagmin-1 to the plasma ...
Houda Yasmine Ali Moussa, Yongsoo Park
doaj +2 more sources
eLife, 2020 The Ca2+ sensor synaptotagmin-1 and the SNARE complex cooperate to trigger neurotransmitter release. Structural studies elucidated three distinct synaptotagmin-1-SNARE complex binding modes involving ‘polybasic’, ‘primary’ and ‘tripartite’ interfaces of ...
Rashmi Voleti +2 more
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Synaptotagmin-7 is an asynchronous calcium sensor for synaptic transmission in neurons expressing SNAP-23. [PDF]
PLoS ONE, 2014 Synchronization of neurotransmitter release with the presynaptic action potential is essential for maintaining fidelity of information transfer in the central nervous system.
Jens P Weber +4 more
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eLife, 2021 Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2 ...
Bassam Tawfik +8 more
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The Role of Calmodulin vs. Synaptotagmin in Exocytosis
Frontiers in Molecular Neuroscience, 2021 Exocytosis is a Ca2+-regulated process that requires the participation of Ca2+ sensors. In the 1980s, two classes of Ca2+-binding proteins were proposed as putative Ca2+ sensors: EF-hand protein calmodulin, and the C2 domain protein synaptotagmin. In the
Renhao Xue +8 more
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Fast resupply of synaptic vesicles requires synaptotagmin-3
Nature, 2022 Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar presynaptic Ca2+ signals by an as-yet unidentified high-affinity Ca2+ sensor1,
Skyler L Jackman
exaly +2 more sources
eLife, 2022 Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon Ca2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes between the vesicle and plasma membranes that are bound to Synaptotagmin-1 ...
Josep Rizo +4 more
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Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release
eLife, 2020 Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how the dopamine secretory system is built to support fast and slow ...
Aditi Banerjee +4 more
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Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Release of neurotransmitters relies on submillisecond coupling of synaptic vesicle fusion to the triggering signal: AP-evoked presynaptic Ca2+ influx.
Bello, Oscar D. +9 more
core +4 more sources
Aging Cell, 2020 Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD.
Rui Zhang, Shunjiang Xu
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