Results 101 to 110 of about 38,926 (261)
Optimal neuromuscular performance requires motor neuron phosphagen kinases
The Journal of Physiology, EarlyView.Abstract figure legend Motor neuron (MN) terminals in fruit flies, mice and humans contain phosphagen kinases, a key enzyme in their energy storage and buffering system. Here we knocked down the primary phosphagen kinase in fruit fly larvae (arginine kinase 1 (ArgK1)) but were surprised to find that MN endurance was unaffected.
Karlis A. Justs +10 more
wiley +1 more source
Different strokes for different synaptotagmins [PDF]
Journal of General Physiology, 2017 JGP study shows how synaptotagmins 1 and 7 affect chromaffin cell granule fusion.
openaire +2 more sources
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
core +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Botulism is induced by Clostridium botulinum neurotoxins (BoNTs). At neuromuscular junctions, BoNT/B binds to dual receptors: a plasma membrane resident polysialoganglioside and synaptotagmin, a synaptic vesicle protein transiently inserted ...
Alessandra Flores +15 more
semanticscholar +1 more source
Brain Pathology, Volume 36, Issue 2, March 2026.Deep learning tissue mapping can guide region of interest selection for spatial transcriptomic analyses. Using this method, a transcriptional catalogue of focal cortical dysplasia type IIb was generated, revealing enrichment for markers of inhibitory glycinergic signaling in cytomegalic dysmorphic neurons.
Ameesha Paliwal +8 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2012 We investigated whether cortical glutamatergic and GABAergic release machineries can be differentiated on the basis of the nature and amount of proteins they express, by performing a quantitative analysis of the degree of co-localization of synaptotagmin
Luca eBragina +8 more
doaj +1 more source
Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells. [PDF]
, 1994 Neurons and endocrine cells have two types of secretory vesicle that undergo regulated exocytosis. Large dense core vesicles (LDCVs) store neural peptides whereas small clear synaptic vesicles store classical neurotransmitters such as acetylcholine ...
Edwards, RH +5 more
core
The rab3A-22A chimera prevents sperm exocytosis by stabilizing open fusion pores [PDF]
, 2016 At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo.
Bustos, Matias Alberto +5 more
core +1 more source
Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder
Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley +1 more source
C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.
The Journal of biological chemistry, 2005 To allow the monitoring of synaptotagmin 1 trafficking in vivo, we generated transgenic mice expressing a synaptotagmin 1-enhanced cyan fluorescent protein (ECFP) fusion protein under control of the Thy1 promoter. Transgenic synaptotagmin 1-ECFP is expressed throughout the brain where it localizes to synapses and marks synapses in vivo.
Han, W. +6 more
openaire +3 more sources