Results 111 to 120 of about 38,926 (261)

MSM/RD: Coupling Markov state models of molecular kinetics with reaction-diffusion simulations [PDF]

, 2018
Molecular dynamics (MD) simulations can model the interactions between macromolecules with high spatiotemporal resolution but at a high computational cost. By combining high-throughput MD with Markov state models (MSMs), it is now possible to obtain long-
De Sancho, David, del Razo, Mauricio J., Dibak, Manuel, Noé, Frank, Schütte, Christof   +4 more
core   +2 more sources

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Unveiling physiological functions of extended synaptotagmins [PDF]

Cell Cycle, 2015
The endoplasmic reticulum (ER) is an extensive membrane network in eukaryotic cells important for many cellular processes. To orchestrate cellular functions, the ER forms junctions with other organelles, where the 2 membranes are closely tethered by protein-lipid and/or protein-protein interactions within 10–25 nm.
Jen, Liou, Chi-Lun, Chang
openaire   +2 more sources

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio
Neurotransmitter release is triggered in microseconds by the two C2 domains of the Ca2+ sensor synaptotagmin‐1 and by SNARE complexes, which form four‐helix bundles that bridge the vesicle and plasma membranes. The synaptotagmin‐1 C2B domain binds to the
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
doaj   +1 more source

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1. [PDF]

, 2016
C2 domains are widespread motifs that often serve as Ca(2+)-binding modules; some proteins have more than one copy. An open issue is whether these domains, when duplicated within the same parent protein, interact with one another to regulate function. In
Bai, Hua, Chapman, Edwin R, Edwardson, J Michael, Evans, Chantell S, He, Zixuan, Jeggle, Pia, Lou, Xiaochu, Sutton, R Bryan   +7 more
core   +2 more sources

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

SYT13: An underestimated synaptotagmin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Synaptotagmin-13 (SYT13) is a non-canonical member of the of synaptotagmin family that, canonical synaptotagmins, doesn't contain Ca2+ binding sites, but still appears to play a key role in the control of different cellular processes such as vesicle transport, cell migration, signaling and cell development.
Lehmann, Johannes, Catanese, Alberto
openaire   +2 more sources

Ring-like Oligomers of Synaptotagmins and Related C2 Domain Proteins [PDF]

, 2016
We recently reported that the C2AB portion of Synaptotagmin 1 (Syt1) could self-assemble into Ca2+-sensitive ring-like oligomers on membranes, which could potentially regulate neurotransmitter release.
Bello, OD, Cai, Y, Coleman, J, Krishnakumar, SS, Rothman, JE, Sindelar, CV, Wang, J, Zanetti, MN   +7 more
core   +1 more source

Synaptotagmin oligomers are necessary and can be sufficient to form a Ca2+‐sensitive fusion clamp

FEBS Letters, 2019
The buttressed‐ring hypothesis, supported by recent cryo‐electron tomography analysis of docked synaptic‐like vesicles in neuroendocrine cells, postulates that prefusion SNAREpins are stabilized and organized by Synaptotagmin (Syt) ring‐like oligomers ...
S. Ramakrishnan, Manindranath Bera, Jeff Coleman, Shyam S. Krishnakumar, F. Pincet, J. Rothman   +5 more
semanticscholar   +1 more source

Membrane Association and Functional Mechanism of Synaptotagmin-1 in Triggering Vesicle Fusion

bioRxiv, 2020
Upon Ca2+ influx, synaptic vesicles fuse with the presynaptic plasma membrane (PM) to release neurotransmitters. Membrane fusion is triggered by synaptotagmin-1, a transmembrane protein in the vesicle membrane (VM), but the mechanism is under debate ...
R. Prasad, Huan‐Xiang Zhou
semanticscholar   +1 more source