Results 121 to 130 of about 38,926 (261)
Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando +7 more
wiley +1 more source
eLifeDespite decades of intense study, the molecular basis of asynchronous neurotransmitter release remains enigmatic. Synaptotagmin (syt) 7 and Doc2 have both been proposed as Ca2+ sensors that trigger this mode of exocytosis, but conflicting findings have ...
Zhenyong Wu +7 more
doaj +1 more source
PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis
Journal of Lipid Research, 2018 The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2].
Ao Hu +9 more
doaj +1 more source
Selective co-expression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea-pig ileum [PDF]
, 2013 Author version made available in accordance with publisher's policy.Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies and neurites composed mainly of the presynaptic protein α-synuclein. Frequently, Lewy bodies and neurites
Brookes, Simon Jonathan +2 more
core +1 more source
Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses
Journal of Neuroscience, 2018 When an action potential invades a presynaptic terminal it evokes large, brief Ca2+ signals that trigger vesicle fusion within milliseconds that is followed by a small residual Ca2+ (Cares) signal.
J. Turecek, W. Regehr
semanticscholar +1 more source
Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 131-143, January 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules
Molecular Biology of the Cell, 2014 Adrenal chromaffin cells release hormones and neuropeptides that are essential for physiological homeostasis. During this process, secretory granules fuse with the plasma membrane and deliver their cargo to the extracellular space. It was once believed that fusion was the final regulated step in exocytosis, resulting in uniform and total release of ...
Rao, Tejeshwar C. +5 more
openaire +2 more sources
Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
Nature Communications, 2019 The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of unknown function, plays no role in exocytosis, and instead
David A Ruhl +15 more
semanticscholar +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park +19 more
wiley +1 more source
RETRACTED: Protein kinase C is a calcium sensor for presynaptic short-term plasticity
eLife, 2014 In presynaptic boutons, calcium (Ca2+) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca2+ to their C2 domains, the proteins that sense ...
Diasynou Fioravante +5 more
doaj +1 more source