Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion [PDF]
eLife, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Jiajie Diao +13 more
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Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
eLife, 2020 Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan +4 more
doaj +2 more sources
Acta Physiologica, 2022 SYT11 and SYT13, two calcium‐insensitive synaptotagmins, are downregulated in islets from type 2 diabetic donors, but their function in insulin secretion is unknown.
J. K. Ofori +8 more
semanticscholar +3 more sources
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
Nature Communications, 2019 Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (syt) 1
Nicholas A Courtney +2 more
exaly +2 more sources
Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release [PDF]
Nature CommunicationsNeurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity.
Dipayan Bose +5 more
doaj +2 more sources
Nature Communications, 2018 Loss-of-function mutations in Parkin are the most common causes of autosomal recessive Parkinson’s disease (PD). Many putative substrates of parkin have been reported; their pathogenic roles, however, remain obscure due to poor characterization ...
Changhe Wang, Li Zhou, Qihui Wu
exaly +2 more sources
The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis
Nature, 2017 Qiangjun Zhou +2 more
exaly +2 more sources
Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
Nature Communications, 2018 Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease.
Gaël Barthet +2 more
exaly +2 more sources
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting
Science, 2019 Ankit Awasthi, Eva Benito, Yo Shinoda
exaly +2 more sources
Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]
, 2012 Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux +68 more
core +17 more sources