Results 21 to 30 of about 38,926 (261)

Palmitoylation of the Parkinson’s disease–associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis

Science Signaling, 2023
Synaptotagmin-11 (Syt11) is a vesicle-trafficking protein that is linked genetically to Parkinson’s disease (PD). Likewise, the protein α-synuclein regulates vesicle trafficking, and its abnormal aggregation in neurons is the defining cytopathology of PD.
Gary P. H. Ho, Erin Wilkie, Andrew J. White, D. Selkoe   +3 more
semanticscholar   +1 more source

Insights into membrane association of the SMP domain of extended synaptotagmin

Nature Communications, 2023
The Synaptotagmin-like Mitochondrial-lipid-binding Protein (SMP) domain is a newly identified lipid transfer module present in proteins that regulate lipid homeostasis at membrane contact sites (MCSs).
Yunyun Wang, Zhenni Li, Xuepeng Wang, Ziyuan Zhao, Li Jiao, Ruming Liu, Keying Wang, Rui Ma, Yang Yang, Guoxun Chen, Yong Wang, Xin Bian   +11 more
semanticscholar   +1 more source

Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending

Advancement of science, 2023
Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorly ...
Houda Y Ali Moussa, K. C. Shin, Janarthanan Ponraj, S. Kim, Je-Kyung Ryu, S. Mansour, Yongsoo Park   +6 more
semanticscholar   +1 more source

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. [PDF]

PLoS ONE, 2010
Synaptotagmins are known to mediate diverse forms of Ca2+-triggered exocytosis through their C2 domains, but the principles underlying functional differentiation among them are unclear.
Mingshan Xue, Timothy K Craig, Ok-Ho Shin, Liyi Li, Chad A Brautigam, Diana R Tomchick, Thomas C Südhof, Christian Rosenmund, Josep Rizo   +8 more
doaj   +1 more source

Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Precise and efficient coupling of endocytosis to exocytosis is critical for neurotransmission. The activity-dependent facilitation of endocytosis has been well established for efficient membrane retrieval; however, whether neural activity ...
Yang Chen, Shaoqin Hu, Xuanang Wu, Zhenli Xie, Yuan Wang, Bianbian Wang, Xiaopeng Li, Yingmei Pei, Yuhao Gu, Kai Huang, Jingxiao Huo, Anqi Wei, Cheng Bi, Zhe Lu, Q. Song, Huadong Xu, Xinjiang Kang, S. Shao, J. Long, Jiankang Liu, Zhuan Zhou, Rong Huang, Z. Chai, Changhe Wang   +23 more
semanticscholar   +1 more source

Arabidopsis synaptotagmin 1 mediates lipid transport in a lipid composition‐dependent manner

Traffic : the International Journal of Intracellular Transport, 2022
The endoplasmic reticulum (ER)‐plasma membrane (PM) contact sites (EPCSs) are structurally conserved in eukaryotes. The Arabidopsis ER‐anchored synaptotagmin 1 (SYT1), enriched in EPCSs, plays a critical role in plant abiotic stress tolerance.
Tiantian Qian, Chenlu Li, Furong Liu, K. Xu, Chun Wan, Yinghui Liu, Haijia Yu   +6 more
semanticscholar   +1 more source

Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration

Nature Communications, 2023
Synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that regulate exocytosis in neuronal and neuroendocrine cells. Upon binding calcium, both proteins partially penetrate lipid bilayers that bear anionic phospholipids, but the specific ...
Kevin C. Courtney, Taraknath Mandal, Nikunj Mehta, Lanxi Wu, Yueqi Li, Debasis Das, Qiang Cui, Edwin R. Chapman   +7 more
doaj   +1 more source

Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion. [PDF]

PLoS ONE, 2011
BACKGROUND:Secretion of insulin and glucagon is triggered by elevated intracellular calcium levels. Although the precise mechanism by which the calcium signal is coupled to insulin and glucagon granule exocytosis is unclear, synaptotagmin-7 has been ...
Phing-How Lou, Natalia Gustavsson, Yue Wang, George K Radda, Weiping Han   +4 more
doaj   +1 more source

Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin secretion is a complex and highly regulated process. It is well established that cytoplasmic calcium is a key regulator of insulin secretion, but how elevated intracellular calcium triggers insulin granule exocytosis remains unclear ...
Natalia Gustavsson, Xiaorui Wang, Yue Wang, Tingting Seah, Jun Xu, George K Radda, Thomas C Südhof, Weiping Han   +7 more
doaj   +1 more source

Synaptotagmins in Neurodegeneration [PDF]

The Anatomical Record, 2009
AbstractSynaptotagmins (Syts) are transmembrane proteins involved in the regulation of membrane trafficking. Here, we summarize literature data that provide growing evidence that several Syts are involved in the pathophysiological mechanisms of temporal lobe epilepsy and Parkinson's disease, as well as few reports related to brain ischemia and ...
Gordana, Glavan, Reinhard, Schliebs, Marko, Zivin   +2 more
openaire   +2 more sources