Results 31 to 40 of about 38,926 (261)

Synaptotagmin-1–, Munc18-1–, and Munc13-1–dependent liposome fusion with a few neuronal SNAREs

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Neurotransmitter release is crucial for neuronal communication. Reproducing the steps that lead to neuronal exocytosis with lipid vesicles and purified proteins provides a powerful strategy to elucidate the molecular mechanisms underlying ...
Karolina P. Stepien, J. Rizo
semanticscholar   +1 more source

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. [PDF]

PLoS Biology, 2015
In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively.
Taulant Bacaj, Dick Wu, Jacqueline Burré, Robert C Malenka, Xinran Liu, Thomas C Südhof   +5 more
doaj   +1 more source

Synaptotagmin-9 in mouse retina

Visual Neuroscience, 2023
Abstract Synaptotagmin-9 (Syt9) is a Ca 2+ sensor mediating fast synaptic release expressed in various parts of the brain. The presence and role of Syt9 in retina is unknown.
Chris S. Mesnard, Cassandra L. Hays, Lou E. Townsend, Cody L. Barta, Channabasavaiah B. Gurumurthy, Wallace B. Thoreson   +5 more
openaire   +3 more sources

Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion

bioRxiv, 2021
Synchronous release at neuronal synapses is accomplished by a machinery that senses calcium influx and fuses the synaptic vesicle and plasma membranes to release neurotransmitters.
Jie Zhu, Z. McDargh, Feng Li, Shyam S. Krishnakumar, J. Rothman, B. O’Shaughnessy   +5 more
semanticscholar   +1 more source

O-GlcNAcase contributes to cognitive function in Drosophila [PDF]

, 2020
Contains fulltext : 219183.pdf (publisher's version ) (Open ...
Catinozzi, Marica, Eidhof, Ilse, Fenckova, Michaela, Ferenbach, Andrew, Muha, Villo, Schenck, Annette, Storkebaum, Erik, van Aalten, Daan   +7 more
core   +3 more sources

Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release

Journal of Neuroscience, 2021
Synaptotagmin-1 (Syt1) is a vesicular calcium sensor required for synchronous neurotransmitter release, composed of a single-pass transmembrane domain linked to two C2 domains (C2A and C2B) that bind calcium, acidic lipids, and SNARE proteins that drive ...
Zhenyong Wu, Lu Ma, Nicholas A. Courtney, Jie Zhu, Ane Landajuela, Yongli Zhang, E. Chapman, E. Karatekin   +7 more
semanticscholar   +1 more source

Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons

eLife, 2023
Neurotransmitter-filled synaptic vesicles (SVs) mediate synaptic transmission and are a hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic nerve terminals remains the subject of debate. The leading model posits that
Emma T Watson, Michaela M Pauers, Michael J Seibert, Jason D Vevea, Edwin R Chapman   +4 more
doaj   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

The binding of botulinum neurotoxins to different peripheral neurons [PDF]

, 2017
Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
core   +1 more source

Synaptotagmin Function Illuminated [PDF]

The Journal of General Physiology, 2003
Neurotransmitter release occurs by exocytosis of synaptic vesicles triggered by Ca2+ influx through voltage-gated Ca2+ channels. It was found many years ago that release shows a steep dependence on extracellular [Ca2+] and increases approximately with the fourth power of [Ca2+] ([Dodge ...
openaire   +3 more sources