Results 41 to 50 of about 38,926 (261)
FEBS Open Bio, 2022 The mechanism of neurotransmitter release has been extensively characterized, showing that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and synaptobrevin. This complex is disassembled by N‐ethylmaleimide sensitive factor (
Josep Rizo +3 more
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LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]
, 2016 Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio +15 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017 The extended-synaptotagmins (tricalbins in yeast) derive their name from their partial domain structure similarity to the synaptotagmins, which are characterized by an N-terminal membrane anchor and cytosolically exposed C2 domains. However, they differ from the synaptotagmins in localization and function.
Saheki, Yasunori, De Camilli, Pietro
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Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]
, 2006 Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium.
A. Scheuber +32 more
core +6 more sources
Differential roles for snapin and synaptotagmin in the synaptic vesicle cycle. [PDF]
PLoS ONE, 2013 Evoked synaptic transmission is dependent on interactions between the calcium sensor Synaptotagmin I and the SNARE complex, comprised of Syntaxin, SNAP-25, and Synaptobrevin.
Szi-Chieh Yu +4 more
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The Arabidopsis Synaptotagmin1 is enriched in endoplasmic reticulum-plasma membrane contact sites and confers cellular resistance to mechanical stresses [PDF]
, 2015 Eukaryotic endoplasmic reticulum (ER)-plasma membrane (PM) contact sites are evolutionarily conserved microdomains that have important roles in specialized metabolic functions such as ER-PM communication, lipid homeostasis, and Ca2+ influx.
Botella, Miguel A +8 more
core +2 more sources
Synaptotagmin II. A novel differentially distributed form of synaptotagmin
Journal of Biological Chemistry, 1991 Synaptotagmin is a synaptic vesicle membrane protein with properties suggestive of a role in synaptic vesicle exocytosis (Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R., and Südhof, T. C. (1990) Nature 345, 260-263). Here, we report the structure of a novel form of synaptotagmin named synaptotagmin II that is highly homologous to the originally ...
M, Geppert, B T, Archer, T C, Südhof
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Biological roles of plant synaptotagmins
European Journal of Cell Biology, 2023 Plant synaptotagmins (SYTs) are resident proteins of the endoplasmic reticulum (ER). They are characterized by an N-terminal transmembrane region and C2 domains at the C-terminus, which tether the ER to the plasma membrane (PM). In addition to their tethering role, SYTs contain a lipid-harboring SMP domain, essential for shuttling lipids between the ER
Francisco Benitez-Fuente +1 more
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eLife, 2016 The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of this process are not fully understood.
Ángel Pérez-Lara +8 more
doaj +1 more source
Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina
Frontiers in Ophthalmology, 2023 IntroductionLight responses of rod photoreceptor cells traverse the retina through three pathways. The primary pathway involves synapses from rods to ON-type rod bipolar cells with OFF signals reaching retinal ganglion cells (RGCs) via sign-inverting ...
Asia L. Sladek +2 more
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