Results 51 to 60 of about 38,926 (261)
Synaptotagmin 13: Structure and expression of a novel synaptotagmin
European Journal of Cell Biology, 2001 Synaptotagmins represent a family of putative vesicular trafficking proteins. With synaptotagmin 13, we have now identified a novel synaptotagmin, making this one of the largest families of trafficking proteins. Similar to synaptotagmins 3, 4, 6, 7, 9, and 11, synaptotagmin 13 is expressed at highest levels in brain but is also detectable at lower ...
C, von Poser, T C, Südhof
openaire +2 more sources
SYT1-Associated Neurodevelopmental Disorder: A Narrative Review
Children, 2022 Synaptic dysregulations often result in damaging effects on the central nervous system, resulting in a wide range of brain and neurodevelopment disorders that are caused by mutations disrupting synaptic proteins. SYT1, an identified synaptotagmin protein,
Edith Riggs +3 more
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Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle
eLife, 2015 In response to Ca2+ influx, a synapse needs to release neurotransmitters quickly while immediately preparing for repeat firing. How this harmonization is achieved is not known. In this study, we found that the Ca2+ sensor synaptotagmin 1 orchestrates the
Yunsheng Cheng +3 more
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Synaptotagmin 13 is neuroprotective across motor neuron diseases
Acta Neuropathologica, 2020 In amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes are spared, including oculomotor neurons (OMNs).
M. Nizzardo +10 more
semanticscholar +1 more source
eLife, 2017 The synaptic vesicle Ca2+ sensor Synaptotagmin binds Ca2+ through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated.
Zhuo Guan +5 more
doaj +1 more source
The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]
, 2012 Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
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Expression and distribution of synaptotagmin family members in the zebrafish retina
The Journal of comparative neurology, 2021 Synaptotagmins belong to a large family of proteins. Although various synaptotagmins have been implicated as Ca2+ sensors for vesicle replenishment and release at conventional synapses, their roles at retinal ribbon synapses remain incompletely ...
D. Henry +3 more
semanticscholar +1 more source
Coming together to define membrane contact sites. [PDF]
, 2019 Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell ...
De Matteis, Maria Antonietta +14 more
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Synaptotagmin gene content of the sequenced genomes
BMC Genomics, 2004 Background Synaptotagmins exist as a large gene family in mammals. There is much interest in the function of certain family members which act crucially in the regulated synaptic vesicle exocytosis required for efficient neurotransmission.
Craxton Molly
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Frontiers in Plant Science, 2020 To infect their hosts and cause disease, plant viruses must replicate within cells and move throughout the plant both locally and systemically. RNA virus replication occurs on the surface of various cellular membranes, whose shape and composition become ...
Amit Levy +3 more
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