Results 71 to 80 of about 38,926 (261)

Extended synaptotagmin regulates membrane contact site structure and lipid transfer function in vivo

EMBO Reports, 2020
Inter‐organelle communication between closely apposed membranes is proposed at membrane contact sites (MCS). However, the regulation of MCS structure and their functional relevance in vivo remain debated.
Vaisaly R Nath, Shirish Mishra, Bishal Basak, Deepti Trivedi, P. Raghu   +4 more
semanticscholar   +1 more source

Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome.

PLoS ONE, 2017
During chemical transmission, the function of synaptic proteins must be coordinated to efficiently release neurotransmitter. Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human neuromuscular junction, has ...
Mallory C Shields, Matthew R Bowers, McKenzie M Fulcer, Madelyn K Bollig, Patrick J Rock, Bryan R Sutton, Alysia D Vrailas-Mortimer, Hanns Lochmüller, Roger G Whittaker, Rita Horvath, Noreen E Reist   +10 more
doaj   +1 more source

Implication of synaptotagmins 4 and 7 in activity-dependent somatodendritic dopamine release in the ventral midbrain

Open Biology, 2022
Dopamine (DA) neurons can release DA not just from axon terminals, but also from their somatodendritic (STD) compartment through a mechanism that is still incompletely understood. Using voltammetry in mouse mesencephalic brain slices, we find that STD DA
Benoît Delignat-Lavaud, Charles Ducrot, Willemieke Kouwenhoven, Nina Feller, Louis-Éric Trudeau   +4 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact

Nature Communications, 2020
Synaptotagmin 1 is a vesicle-anchored membrane protein that functions as the Ca2+ sensor for synchronous neurotransmitter release. In this work, an arginine containing region in the second C2 domain of synaptotagmin 1 (C2B) is shown to control the ...
Sarah B. Nyenhuis, Nakul Karandikar, V. Kiessling, Alex J. B. Kreutzberger, A. Thapa, B. Liang, L. Tamm, D. Cafiso   +7 more
semanticscholar   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release [PDF]

Neuron, 2013
In forebrain neurons, knockout of synaptotagmin-1 blocks fast Ca(2+)-triggered synchronous neurotransmitter release but enables manifestation of slow Ca(2+)-triggered asynchronous release. Here, we show using single-cell PCR that individual hippocampal neurons abundantly coexpress two Ca(2+)-binding synaptotagmin isoforms, synaptotagmin-1 and ...
Bacaj, Taulant, Wu, Dick, Yang, Xiaofei, Morishita, Wade, Zhou, Peng, Xu, Wei, Malenka, Robert C., Südhof, Thomas C.   +7 more
openaire   +2 more sources

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics

Toxins, 2018
Botulinum neurotoxins (BoNTs) are categorised into immunologically distinct serotypes BoNT/A to /G). Each serotype can also be further divided into subtypes based on differences in amino acid sequence. BoNTs are ~150 kDa proteins comprised of three major
Jonathan R. Davies, Sai Man Liu, K. Ravi Acharya   +2 more
doaj   +1 more source

Hormone-stimulated modulation of endocytic trafficking in osteoclasts [PDF]

, 2012
Copyright @ 2012 Stenbeck, Lawrence and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and ...
Albert, AP, Lawrence, KM, Stenbeck, G
core   +2 more sources

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source