Results 81 to 90 of about 38,926 (261)
Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb [PDF]
, 2009 Fucose-α(1−2)-galactose [Fucα(1−2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of information regarding
Domino, Steven E. +5 more
core +4 more sources
Nature Neuroscience, 2017 The synaptic vesicle (SV) protein synaptotagmin-1 (Syt1) is the Ca2+ sensor for fast synchronous release. Biochemical and structural data suggest that Syt1 interacts with phospholipids and SNARE complex, but the manner in which these interactions ...
Shuwen Chang +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke +14 more
wiley +1 more source
Complexin/Synaptotagmin Interplay Controls Acrosomal Exocytosis [PDF]
Journal of Biological Chemistry, 2007 La secreción regulada es un proceso fundamental que subyace a la función de muchos tipos de células. En particular, la exocitosis acrosómica en espermatozoides de mamíferos es esencial para la fertilización de óvulos. La secreción regulada requiere proteínas SNARE y, en las neuronas, también sinaptotagmina I y complexina.
Carlos M. Roggero +5 more
openaire +2 more sources
Regulated Mucin Secretion from Airway Epithelial Cells
Frontiers in Endocrinology, 2013 Secretory epithelial cells of the proximal airways synthesize and secrete gel-forming polymeric mucins. The secreted mucins adsorb water to form mucus that is propelled by neighboring ciliated cells, providing a mobile barrier which removes inhaled ...
Kenneth Bruce Adler +2 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Bladder exstrophy and epispadias complex (BEEC) is one of the most severe congenital malformations of the urogenital tract, significantly impacting continence, sexual function, and renal function. To date, the only recurrent genetic aberration identified is the 22q.11.2 microduplication, but several candidate regions and genes including ...
Agneta Nordenskjöld +9 more
wiley +1 more source
Targeting of synaptotagmin to neurite terminals in neuronally differentiated PC12 cells [PDF]
, 2000 We have investigated structural elements that determine the accumulation of synaptotagmin, a major synaptic vesicle protein, in neurite terminals of neuronally differentiated neuroendocrine pheochromocytoma PC12 cells. We performed extensive deletion and
Enikolopov, G., Krasnov, P. A.
core
Genes & Development, 2019 Shimojo et al. show that Synaptotagmin-11 is an essential component of a neuronal vesicular trafficking pathway that differs from the well-characterized synaptic vesicle trafficking pathway but is also essential for life.
Masafumi Shimojo +6 more
semanticscholar +1 more source
New insights into epileptic spasm generation and treatment from the TTX animal model
Epilepsia Open, EarlyView.Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source
Synaptotagmin Binding to Botulinum Neurotoxins
Biochemistry, 2019 Botulinum neurotoxins (BoNTs) are exceptionally toxic proteins that cause paralysis but are also extensively used as treatment for various medical conditions. Most BoNTs bind two receptors on neuronal cells, namely, a ganglioside and a protein receptor.
Markel Martínez-Carranza +6 more
openaire +4 more sources