Results 1 to 10 of about 17,463,190 (178)

T-BET and EOMES sustain mature human NK cell identity and antitumor function [PDF]

The Journal of Clinical Investigation, 2023
Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear.
Pamela Wong, Jennifer A. Foltz, Lily Chang, Carly C. Neal, Tony Yao, Celia C. Cubitt, Jennifer Tran, Samantha Kersting-Schadek, Sathvik Palakurty, Natalia Jaeger, David A. Russler-Germain, Nancy D. Marin, Margery Gang, Julia A. Wagner, Alice Y. Zhou, Miriam T. Jacobs, Mark Foster, Timothy Schappe, Lynne Marsala, Ethan McClain, Patrick Pence, Michelle Becker-Hapak, Bryan Fisk, Allegra A. Petti, Obi L. Griffith, Malachi Griffith, Melissa M. Berrien-Elliott, Todd A. Fehniger   +27 more
doaj   +3 more sources

T-bet⁺ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity. [PDF]

Cell Metab, 2022
Obesity is accompanied by inflammation in adipose tissue, impaired glucose tolerance, and changes in adipose leukocyte populations. These studies of adipose tissue from humans and mice revealed that increased frequencies of T-bet+ B cells in adipose ...
Hägglöf T, Vanz C, Kumagai A, Dudley E, Ortega V, Siller M, Parthasarathy R, Keegan J, Koenigs A, Shute T, Leadbetter EA.   +10 more
europepmc   +2 more sources

Identification and Characterization of a Master Transcription Factor of Th1 Cells, T-bet, Within Flounder (Paralichthys olivaceus)

Frontiers in Immunology, 2021
T-bet, a T-box family member, is a transcription factor essential for the differentiation of naive CD4+ T cells into Th1 cells that are involved in both innate and adaptive immune responses.
Hongfei Tian, Jing Xing, Jing Xing, Xiaoqian Tang, Xiaoqian Tang, Heng Chi, Xiuzhen Sheng, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +2 more sources

Expression Regulation and Function of T-Bet in NK Cells. [PDF]

Front Immunol, 2021
Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is ...
Huang C, Bi J.
europepmc   +2 more sources

Human T-bet governs the generation of a distinct subset of CD11c^highCD21^low B cells. [PDF]

Sci Immunol, 2022
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct murine B cell population known as “age-associated B cells” (ABCs). T-bet–deficient mice have reduced ABCs and impaired humoral immunity. We describe a patient
Yang R, Avery DT, Jackson KJL, Ogishi M, Benhsaien I, Du L, Ye X, Han J, Rosain J, Peel JN, Alyanakian MA, Neven B, Winter S, Puel A, Boisson B, Payne KJ, Wong M, Russell AJ, Mizoguchi Y, Okada S, Uzel G, Goodnow CC, Latour S, El Bakkouri J, Bousfiha A, Preece K, Gray PE, Keller B, Warnatz K, Boisson-Dupuis S, Abel L, Pan-Hammarström Q, Bustamante J, Ma CS, Casanova JL, Tangye SG.   +35 more
europepmc   +2 more sources

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells

Frontiers in Immunology, 2021
T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK cells and failure to control tumor growth. In contrast
Laura Kiekens, Laura Kiekens, Wouter Van Loocke, Wouter Van Loocke, Sylvie Taveirne, Sylvie Taveirne, Sigrid Wahlen, Sigrid Wahlen, Eva Persyn, Eva Persyn, Els Van Ammel, Els Van Ammel, Zenzi De Vos, Zenzi De Vos, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Tom Taghon, Pieter Van Vlierberghe, Pieter Van Vlierberghe, Bart Vandekerckhove, Bart Vandekerckhove, Georges Leclercq, Georges Leclercq   +23 more
doaj   +2 more sources

Identification of the T-box transcription factor t-bet in chickens and its role in immune response [PDF]

Poultry Science
T-bet (T-box transcription factor TBX21), encoded by the Tbx21 gene, is a key regulator of T helper 1 (Th1) cell differentiation and cellular immunity. However, the role of T-bet in avian species remains elusive. To investigate the role of T-bet in avian
Yuxin Guo, Zhaocan Zhou, Hui Gao, Shujun Zhang, Zhi Chen, He Chang, Hong Cao, Li Gao, Yongqiang Wang, Shijun J. Zheng   +9 more
doaj   +2 more sources

T-bet controls severity of hypersensitivity pneumonitis [PDF]

Journal of Inflammation, 2011
Hypersensitivity Pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens. The disease is characterized by alveolitis, granuloma formation and in some patients' fibrosis.
Nance Stephanie C, Desai Meena, Abdelsamed Hossam, Fitzpatrick Elizabeth A   +3 more
doaj   +3 more sources

The effect of glatiramer acetate, IFNβ-1a, fingolimod, and dimethyl fumarate on the expression of T-bet, IFN-γ, and MEG3 in PBMC of RRMS patients [PDF]

BMC Research Notes, 2023
Objective Multiple sclerosis (MS) is a progressing neurodegenerative disease marked by chronic central nervous system inflammation and degeneration.This study investigates gene expression profiles of T-box transcription factor TBX21 (T-bet), interferon ...
Rozhin Dabbaghi, Reza Safaralizadeh, Shima Rahmani, Nesa Barpour, Mohammadali Hosseinpourfeizi, Ali Rajabi, Behzad Baradaran   +6 more
doaj   +2 more sources

T-bet + B Cells in Humans: Protective and Pathologic Functions. [PDF]

Transplantation, 2023
The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation have identified a novel human B-cell subset that ...
Nellore A, Zumaquero E, Seifert M.
europepmc   +3 more sources