Results 11 to 20 of about 17,484,371 (316)
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. [PDF]
PLoS ONE, 2013 Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
Gang Li +6 more
doaj +14 more sources
Vaccine adjuvant-elicited CD8+ T cell immunity is co-dependent on T-bet and FOXO1 [PDF]
Cell Reports, 2023 Summary: T-bet and FOXO1 are transcription factors canonically associated with effector and memory T cell fates, respectively. During an infectious response, these factors direct the development of CD8+ T cell fates, where T-bet deficiency leads to ...
Daria L. Ivanova +8 more
doaj +2 more sources
T‐bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells [PDF]
Advanced ScienceT‐bet, encoded by TBX21, is extensively expressed across various immune cell types, and orchestrates critical functions in their development, survival, and physiological activities.
Lang Chen +8 more
doaj +2 more sources
T-bet syndrome-associated bronchial asthma phenotype
Медицинская иммунология, 2020 We aimed to evaluate a significance of T-bet transcription factor in bronchial asthma (BA). A total of 102 patients with BA were examined. The control group was represented by healthy subjects (21 people).
L. N. Sorokina +3 more
doaj +3 more sources
T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells
Frontiers in Immunology, 2021 Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD).
Jan-Hendrik Schroeder +11 more
doaj +2 more sources
T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells [PDF]
Frontiers in Immunology, 2022 Type 3 innate lymphoid cells (ILC3s) are characterized by RORγt expression and they produce IL-22 upon activation. ILC3s play a role in maintenance of barrier integrity in the intestine.
Laura Kiekens +13 more
doaj +2 more sources
T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity [PDF]
Journal for ImmunoTherapy of CancerBackground T cells modified to express a chimeric antigen receptor (CAR) are successful against B-lineage malignancies but fail to induce durable remissions in up to half of patients and have shown limited efficacy against other types of cancer ...
M. Eric Kohler +7 more
doaj +2 more sources
Frontiers in Immunology, 2021 Innate lymphoid cells (ILC) play a significant role in the intestinal immune response and T-bet+ CD127+ group 1 cells (ILC1) have been linked to the pathogenesis of human inflammatory bowel disease (IBD). However, the functional importance of ILC1 in the
Jan-Hendrik Schroeder +17 more
doaj +2 more sources
c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells
eLife, 2020 RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22.
Caroline Tizian +9 more
doaj +2 more sources
Frontiers in Immunology, 2019 Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation. Previous studies suggest transcription factor T-bet plays an important role in inflammatory arthritis.
Qi-Bin Yang +5 more
doaj +2 more sources