Results 21 to 30 of about 17,484,371 (316)
"T-bet"-ing on autoimmunity variants. [PDF]
PLoS Genetics, 2017 Michelle L T Nguyen +2 more
doaj +6 more sources
T-Bet Deficiency Attenuates Bile Duct Injury in Experimental Biliary Atresia [PDF]
Cells, 2021 Biliary atresia (BA) is an obstructive neonatal cholangiopathy leading to liver cirrhosis and end stage liver disease. A Kasai portoenterostomy may restore biliary drainage, but most patients ultimately require liver transplantation for survival.
Sujit K. Mohanty +5 more
doaj +2 more sources
Evaluation of IFN-γ and T-bet Expression Levels as Possible Molecular Markers of Schizophrenia [PDF]
Journal of Cell and Molecular Research, 2020 Schizophrenia is an irritating mental disorder that affects around 1% of the world's population. The immune system contributes to the onset of the disease, particularly through production and secretion of some cytokines.
Roghaye Lorestani +3 more
doaj +1 more source
Characterization of T-bet and eomes in peripheral human immune cells. [PDF]
, 2014 The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as key drivers of immune cell development and cytolytic function. While the majority of studies have defined the roles of these factors in the context of murine T-cells,
Betts, Michael R. +3 more
core +13 more sources
Сучасна педіатрія: Україна, 2022 Некротизуючий ентероколіт (НЕК) - тяжке гастроінтестинальне захворювання, що уражує переважно недоношених немовлят. Неспецифічність клінічної картини та високий відсоток ускладнень обумовлюють необхідність ранньої діагностики та профілактики захворювання.
O.E. Abaturov, A.O. Tovarnytska
doaj +1 more source
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells
Nature Communications, 2021 EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate that EOMES and T-BET regulate largely distinct gene sets during this process.
Jiang Zhang +19 more
semanticscholar +1 more source
Immunity, 2022 Adaptive CD4+ T helper cells and their innate counterparts, innate lymphoid cells, utilize an identical set of transcription factors (TFs) for their differentiation and functions.
Difeng Fang +12 more
semanticscholar +1 more source
Immunity, 2017 In this issue of Immunity, Iwata et al. (2017) report that the transcription factor T-bet acts as a selective repressor of the type I interferon (IFN) transcriptional program in response to IFN-γ signaling.
Vanja, Lazarevic +2 more
openaire +2 more sources
Nature Immunology, 2011 The activation of immune-defense mechanisms in response to a microbial attack must be robust and appropriately tailored to fight particular types of pathogens. Infection with intracellular microorganisms elicits a type 1 inflammatory response characterized by mobilization of T helper type 1 (T(H)1) cells to the site of infection, where they are ...
Vanja, Lazarevic, Laurie H, Glimcher
openaire +2 more sources
T‐bet or not T‐bet: Taking the last bow on the autoimmunity stage [PDF]
European Journal of Immunology, 2013 The search for the encephalitogenic factor driving pathogenic T cells in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis (MS), and psoriasis has proven to be a long and difficult mission, which is not yet completed. In this issue of the European Journal of Immunology, the importance of the transcription factor T‐bet, previously ...
Spath, Sabine, Becher, Burkhard
openaire +3 more sources