Results 31 to 40 of about 17,484,371 (316)
Scientific Reports, 2021 T-bet is a key transcription factor for the T helper 1 lineage and its expression level is negatively correlated to inflammation in patients with rheumatoid arthritis (RA).
Masaru Shimizu +8 more
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Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity
Nature Communications, 2022 CD11c + T-bet + B cells are recognized as an important component of humoral immunity and autoimmunity. These cells can be distinguished from other B cells by their higher expression of the adenosine receptor 2a.
Russell C. Levack +6 more
semanticscholar +1 more source
Asthma: T-bet — A Master Controller? [PDF]
Current Biology, 2002 The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma.
Robinson, Douglas S, Lloyd, Clare M
openaire +2 more sources
Temporal Dissection of T-bet Functions [PDF]
The Journal of Immunology, 2007 Abstract T-bet is a transcription factor of the T-box family that regulates the expression of numerous immune system-associated genes. T-bet directs the acquisition of the Th1-associated genetic program in differentiating CD4+ lymphocytes.
Jennifer L, Matsuda +3 more
openaire +2 more sources
Anti-proliferative Activity of T-bet [PDF]
Immune Network, 2015 T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4(+) precursor cells. Since T-bet directly binds to the promoter of the IFN-γ gene and activates its transcription, T-bet deficiency impairs IFN-γ production in Th1 cells.
Oh, Yeon Ji +3 more
openaire +2 more sources
T-bet Orchestrates CD8αα IEL Differentiation [PDF]
Immunity, 2014 Very little is known about the transcription factor network that regulates the development of intestinal intraepithelial lymphocytes (IELs). In this issue of Immunity, Klose et al. (2014b) and Reis et al. (2014) demonstrate an essential role for T-bet in regulating the CD8αα IEL differentiation program.
Kwong, Brandon, Lazarevic, Vanja
openaire +2 more sources
Nature Immunology, 2021 The generation of lymphoid tissues during embryogenesis relies on group 3 innate lymphoid cells (ILC3) displaying lymphoid tissue inducer (LTi) activity and expressing the master transcription factor RORγt. Accordingly, RORγt-deficient mice lack ILC3 and
Christina Stehle +13 more
semanticscholar +1 more source
Zdorovʹe Rebenka, 2023 Background. Breast milk (BM) is an optimal nutritional product for newborns and a source of exogenous microRNAs (miR). MiR-148a is one of the most highly expressed miR of BM. Currently, there is a lack of data on the miR-148a effect on the development of
O.E. Abaturov, A.O. Tovarnytska
doaj +1 more source
PLoS Pathogens, 2021 Host resistance against intracellular pathogens requires a rapid IFN-γ mediated immune response. We reveal that T-bet-dependent production of IFN-γ is essential for the maintenance of inflammatory DCs at the site of infection with a common protozoan ...
A. López-Yglesias +6 more
semanticscholar +1 more source
A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity
Cell Reports, 2023 Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions.
Masaaki Okamoto +7 more
doaj +1 more source