Results 41 to 50 of about 17,484,371 (316)
Science immunology, 2021 T-bet–expressing T and B lymphocytes form a spatiotemporal circuit that enables optimal antiviral humoral immunity. The right place at the right time Protective humoral immunity against viral infections requires an effective type 1 immune response by ...
A. Mendoza +8 more
semanticscholar +1 more source
Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria
Cell, 2020 Inborn errors of human IFN-γ immunity underlie mycobacterial disease. We report a patient with mycobacterial disease due to an inherited deficiency of the transcription factor T-bet.
Rui Yang +49 more
semanticscholar +1 more source
JCI Insight, 2021 Th17 cells are involved in rheumatoid arthritis (RA) pathogenesis. Our previous studies have revealed that transcription factor Yin Yang 1 (YY1) plays an important role in the pathogenic mechanisms of RA.
Jinpiao Lin +7 more
semanticscholar +1 more source
NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice [PDF]
, 2018 Innate lymphoid cells (ILCs) producing IL-22 and/or IL-17, designated as ILC3, comprise a heterogeneous subset of cells involved in regulation of gut barrier homeostasis and inflammation.
Kanno, Yuka +7 more
core +1 more source
T-bet−/− RAG2−/− ulcerative colitis: The role of T-bet as a peacekeeper of host–commensal relationships [PDF]
Cytokine, 2009 Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1].
Wendy S, Garrett, Laurie H, Glimcher
openaire +2 more sources
Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]
, 2019 Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi +3 more
core +2 more sources
Cell Metabolism, 2013 Although increasing adiposity is usually associated with adipose tissue infiltration by inflammatory cells and systemic insulin resistance, Stolarczyk et al. (2013) report in this issue that mice deficient in the T-box transcription factor, T-bet, display a dissociated phenotype with enhanced perigonadal adipose but enhanced insulin sensitivity.
openaire +2 more sources
T-bet regulates T-independent IgG2a class switching [PDF]
International Immunology, 2003 The IgG2a Ig subclass plays a critical role in the pathogenesis of humoral autoimmunity and protection against pathogens. The T-box transcription factor T-bet has been implicated as a critical mediator of class-switch recombination (CSR) to IgG2a, but its relative importance to this process in various immune contexts remains incompletely defined.
Andrea J, Gerth +2 more
openaire +2 more sources
High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency
Journal of Experimental Medicine, 2021 This study describes the multiple facets and molecular basis of excessive Th2 cytokine production by CD4+ αβ T lymphocytes as a possible mechanism underlying persistent upper airway inflammation and blood eosinophilia in a patient with inherited complete
Rui Yang +21 more
semanticscholar +1 more source
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection [PDF]
, 2015 ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition-dependent tumor metastasis.
Agata Stryjewska +72 more
core +3 more sources