Results 51 to 60 of about 17,484,371 (316)

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease [PDF]

, 2017
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity.
Franke, L, Giambartolomei, C, Goldberg, R, Henderson, S, Herrero, J, Hertweck, A, Jenner, RG, Lord, GM, Mohamed, R, Perucha, E, Plagnol, V, Soderquest, K   +11 more
core   +14 more sources

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites [PDF]

, 2014
The transcription factor T-bet (Tbox protein expressed in T cells) is one of the master regulators of both the innate and adaptive immune responses. It plays a central role in T-cell lineage commitment, where it controls the T[subscript H]1 response, and
Brandt, Gabriel S., Dekker, Job, Glimcher, Laurie H, Hoang, Quyen Q., Hwang, Eun Sook, Lazarevic, Vanja, Liu, Ce Feng, Naumova, Natalia, Petsko, Gregory A., Ringe, Dagmar   +9 more
core   +1 more source

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Cell Reports, 2019
Summary: Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular helper (TFH) cells express the prototypical T helper 1 transcription factor T-bet ...
Amania A. Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C. Duckworth, Nicholas D. Huntington, James J. Moon, Marc Pellegrini, Stephen L. Nutt, Gabrielle T. Belz, Kim L. Good-Jacobson, Joanna R. Groom   +12 more
doaj   +1 more source

IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy. [PDF]

, 2013
IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting the protective T regulatory cells in allergic asthma. TH17 cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced ...
Finotto, S., Graser, A., Koch, S., Lehr, H.A., Mousset, S., Reinhardt, C., Reppert, S., Rieker, R., Ubel, C., Zimmermann, T.   +9 more
core   +2 more sources

mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation [PDF]

The Journal of Immunology, 2017
Abstract CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothesis, we employed targeted mass-
Olesya Chornoguz, Robert S Hagan, Azeb Haile, Matthew L Arwood, Christopher J Gamper, Arnob Banerjee, Jonathan D Powell   +6 more
openaire   +2 more sources

T‐bet as a key regulator of mucosal immunity [PDF]

Immunology, 2016
SummaryInitially understood to be a key regulator of interferon‐γ‐producing helper T cells, our knowledge of T‐bet's functional roles has expanded to encompass a growing range of cellular lineages. In addition to regulating other interferon‐γ‐producing adaptive immune cells, it is now clear that T‐bet plays a fundamental role in the regulation of ...
Mohamed, Rami, Lord, Graham M.
openaire   +5 more sources

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht, Edelmann, Martin, Fischer, Rainald, Huber, Rudolf M., Kellner, Julia, Oelmez, Hamza, Tantzscher, Juliane   +6 more
core   +1 more source

Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

BMC Cancer, 2018
Background We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome.
Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull, Irene L. Andrulis   +7 more
doaj   +1 more source

T-bet terminates self-renewal [PDF]

The Journal of Experimental Medicine, 2007
A T cell transcription factor favors short-term benefits over long-term stability, according to a new study by Intlekofer et al. (page 2015). Figure 1 The transcription factor T-bet is expressed mainly in TEM cells. Long-term protection against pathogens by CD8+ T cells is due to a self-renewing population of central memory ...
openaire   +1 more source

Clinical significance of T-bet, GATA-3, and Bcl-6 transcription factor expression in bladder carcinoma [PDF]

, 2016
International audienceBackground: The aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 in bladder cancer in Tunisian patients.Methods: Expression of T-bet, GATA-3 ...
Bahria-Sediki, Islem Ben, Bettaieb, Ali, Chebil, Mohamed, Cherif, Mohamed, El Gaaied, Amel Ben Ammar, Paul, Catherine, Yousfi, Nadhir, Zermani, Rachida   +7 more
core   +3 more sources