Results 61 to 70 of about 17,484,371 (316)

The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection

Clinical and Developmental Immunology, 2013
Background. Previous data showed that the predominance of intraglomerular T-bet or GATA3 is correlated with different mechanisms of rejection, suggesting that the ratio of T-bet/GATA3 might be used to distinguish antibody-mediated rejection (ABMR) and T ...
Xue Li, Qiquan Sun, Mingchao Zhang, Jinsong Chen, Zhihong Liu   +4 more
doaj   +1 more source

Stability and function of regulatory T cells expressing the transcription factor T-bet

Nature, 2017
Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (TH1), TH2, and TH17) defined by expression of the key transcription ...
Andrew G Levine, Alejandra Medoza, S. Hemmers, Bruno Moltedo, R. Niec, Michail Schizas, Beatrice Hoyos, E. Putintseva, A. Chaudhry, Stanislav Dikiy, S. Fujisawa, D. Chudakov, P. Treuting, A. Rudensky   +13 more
semanticscholar   +1 more source

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

Nature Communications, 2019
Understanding the intrinsic mediators that render CD8+ T cells dysfunctional in the tumor microenvironment is a requirement to develop more effective cancer immunotherapies.
Yu Cao, J. Trillo-Tinoco, Rosa A. Sierra, C. Anadon, Wenjie Dai, Eslam Mohamed, L. Cen, T. Costich, A. Magliocco, D. Marchion, R. Klar, Sven Michel, F. Jaschinski, R. Reich, S. Mehrotra, J. Cubillos-Ruiz, D. Munn, J. Conejo-Garcia, P. Rodriguez   +18 more
semanticscholar   +1 more source

Ca-signaling in airway smooth muscle cells is altered in T-bet knock-out mice [PDF]

, 2006
Background: Airway smooth muscle cells (ASMC) play a key role in bronchial hyperresponsiveness (BHR). A major component of the signaling cascade leading to ASMC contraction is calcium.
L Benayoun, JG Martin, NL Stephens, NL Stephens, Y Amrani, CM Pabelick, MJ Berridge, MJ Berridge, MD Bootman, Y Amrani, K Parameswaran, FC Tao, FC Tao, A Bergner, Y Amrani, JM Madison, JL Pype, CM Yang, DA Deshpande, MF Ethier, SY Eum, O Tliba, DA Deshpande, DA Deshpande, AC Mullen, S Finotto, A Bergner, A Bergner, QT Nguyen, MJ Sanderson, S Finotto, RJ Dandurand, C Martin, KH Kuo, JF Perez, KL Massey, YS Prakash   +36 more
core   +2 more sources

T-bet expression is upregulated in active Behcet's disease [PDF]

British Journal of Ophthalmology, 2003
To investigate T-bet mRNA and protein expression on peripheral blood mononuclear cells (PBMC) in patients with Behçet's disease with active uveitis.Blood samples were taken from 24 patients with Behçet's disease who had active uveitis and 16 healthy individuals. PBMC were subjected to analysis of T-bet mRNA and protein expression using semiquantitative
B, Li, P, Yang, H, Zhou, Z, Zhang, C, Xie, X, Lin, X, Huang, A, Kijlstra   +7 more
openaire   +2 more sources

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. [PDF]

, 2017
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts.
Critchfield, JW, Deeks, SG, Ganesh, A, Hecht, FM, Hunt, PW, Kiniry, BE, Shacklett, BL, Somsouk, M   +7 more
core   +1 more source

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]

, 2010
Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert, Bhat, Roopa, Chawla, Ajay, Dugas, Jason C, Dunn, Shannon E, Johnson, Amanda, Moshkova, Marina, Mukundan, Lata, Nguyen, Kim, Sobel, Raymond A, Steinman, Lawrence, Straus, Daniel S   +11 more
core   +3 more sources

T‐bet+ memory B cells: Generation, function, and fate

Immunological Reviews, 2019
B cells expressing the transcription factor T‐bet have emerged as participants in a number of protective and pathogenic immune responses. T‐bet+ B cells characteristically differentiate in response to combined Toll‐like receptor and cytokine signaling ...
James J Knox, A. Myles, M. Cancro
semanticscholar   +1 more source

Highly polarized T h17 cells induce EAE via a T ‐bet independent mechanism [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101823/1/eji2739-sup-0001-FigureS1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/101823/2/eji2739-sup-0001-FigS1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/101823/3/eji2739-sup ...
Axtell, Bettelli, Carlson, Codarri, Duhen, El-Behi, Ferber, Frisullo, Gocke, Haak, Hirota, King, Kroenke, Kroenke, Kurschus, Lee, Lexberg, Lord, Lovett-Racke, Mukasa, Mullen, Muranski, Nath, Szabo, Yang   +24 more
core   +1 more source

Genetic copy number variation of TLR7, T-bet, IL12B, and FcγRIIIB in Egyptian ankylosing spondylitis patients

African Journal of Laboratory Medicine
Background: Ankylosing spondylitis (AS) is a polygenic disorder. Copy number variations (CNVs) alter the expression of TLR7, T-bet, IL-12B, and FcγRIIIB genes, contributing to AS development via their immune system roles.
Nora M. Said, Enas M. Mekkawy, Dina Said, Dina G. Abdelhamed, Alia A. El Shahawy, Eman A. Abdelaziz, Fatma Z. Kamel, Alshymaa A. Ahmed   +7 more
doaj   +1 more source