Results 71 to 80 of about 17,484,371 (316)

Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2

Clinical and Developmental Immunology, 2012
T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx.
Yan Xu, Jingjing Gao, Zhaoliang Su, Xiaoli Dai, Yazhen Li, Yingzhao Liu, Jianguo Chen, Jia Tong, Yun Zhang, Chaoyang Wu, Dong Zheng, Shengjun Wang, Huaxi Xu   +12 more
doaj   +1 more source

Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation [PDF]

Immunity, 2014
The intestinal epithelium harbors large populations of activated and memory lymphocytes, yet these cells do not cause tissue damage in the steady state. We investigated how intestinal T cell effector differentiation is regulated upon migration to the intestinal epithelium. Using gene loss- and gain-of-function strategies, as well as reporter approaches,
Reis, Bernardo S., Hoytema van Konijnenburg, David P., Grivennikov, Sergei I., Mucida, Daniel   +3 more
openaire   +2 more sources

Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells. [PDF]

, 2008
EBV-induced gene 3 (EBI-3) codes for a soluble type I receptor homologous to the p40 subunit of IL-12 that is expressed by APCs following activation. In this study, we assessed the role of EBI-3 in a model of lung melanoma metastasis.
Birkenbach, M., Blumberg, R.S., Finotto, S., Karwot, R., Lehr, H.A., Maxeiner, J.H., Sauer, K.A., Scholtes, P.   +7 more
core   +2 more sources

Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells

Frontiers in Immunology, 2020
Recent reports have shown the importance of IFN-γ and T-bet+ B cells in the pathology of SLE, suggesting the involvement of IFN-γ-producing T-bet+ CD4+ cells, i.e., Th1 cells.
Shigeru Iwata, Mingzeng Zhang, Mingzeng Zhang, He Hao, He Hao, Gulzhan Trimova, Gulzhan Trimova, Maiko Hajime, Yusuke Miyazaki, Naoaki Ohkubo, Yurie Satoh Kanda, Yasuyuki Todoroki, Hiroko Miyata, Masanobu Ueno, Atsushi Nagayasu, Shingo Nakayamada, Kei Sakata, Kei Sakata, Yoshiya Tanaka   +18 more
doaj   +1 more source

Distinct Effector Programs of Brain-Homing CD8⁺ T Cells in Multiple Sclerosis

Cells, 2022
The effector programs of CD8+ memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8+ memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed blood, CSF
Steven C. Koetzier, Jamie van Langelaar, Marie-José Melief, Annet F. Wierenga-Wolf, Cato E. A. Corsten, Katelijn M. Blok, Cindy Hoeks, Bieke Broux, Beatrijs Wokke, Marvin M. van Luijn, Joost Smolders   +10 more
doaj   +1 more source

Tipifarnib-mediated suppression of T-bet-dependent signaling pathways [PDF]

Cancer Immunology, Immunotherapy, 2011
Large granular lymphocyte (LGL) leukemia is a chronic lymphoproliferative disease in which T-bet [T-box transcription factor 21 gene (tbx21)] overexpression may play a pathogenic role. T-bet orchestrates the differentiation of mature peripheral T-cells into interferon-γ (IFN-γ) and tumor necrosis factor-α producing CD4+ T-helper type I (Th1) and CD8+ T
Fanqi, Bai, Alejandro V, Villagra, Jianxiang, Zou, Jeffrey S, Painter, Kirby, Connolly, Michelle A, Blaskovich, Lubomir, Sokol, Said, Sebti, Julie Y, Djeu, Thomas P, Loughran, Sheng, Wei, Eduardo, Sotomayor, Pearlie, Epling-Burnette   +12 more
openaire   +2 more sources

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation

Science Translational Medicine, 2019
During viremia, the HIV-specific memory response in lymph nodes is mediated by T-bethi B cells that inefficiently participate in affinity selection. Abrogated antibody responses in chronic infection Despite the presence of abundant and persistent antigen,
J. Austin, C. Buckner, L. Kardava, Wei Wang, Xiaozhen Zhang, Valerie A. Melson, R. Swanson, A. Martins, Julian Q. Zhou, Kenneth B. Hoehn, J. Fisk, Y. Dimopoulos, Alexander Chassiakos, S. O'Dell, Margery G. Smelkinson, Catherine A. Seamon, Richard W. Kwan, M. Sneller, S. Pittaluga, N. Doria-Rose, A. McDermott, Yuxing Li, Yuxing Li, T. Chun, S. Kleinstein, J. Tsang, C. Petrovas, S. Moir   +27 more
semanticscholar   +1 more source

T-bet employs diverse regulatory mechanisms to repress transcription [PDF]

Trends in Immunology, 2012
Lineage-defining transcription factors are responsible for activating the signature genes required for a given cell fate. They are also needed to repress the genetic programs associated with alternative lineage decisions. The T-box transcription factor T-bet is required for CD4(+) T helper 1 (Th1) cell differentiation.
Kenneth J, Oestreich, Amy S, Weinmann
openaire   +2 more sources

Signals that drive T-bet expression in B cells [PDF]

Cellular Immunology, 2017
Transcription factors regulate various developmental and functional aspects of B cells. T-bet is a recently appreciated transcription factor associated with "Age-associated B cells" or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by ...
Arpita, Myles, Patricia J, Gearhart, Michael P, Cancro   +2 more
openaire   +2 more sources

CD11c+ T-bet+ B Cells Require IL-21 and IFN-γ from Type 1 T Follicular Helper Cells and Intrinsic Bcl-6 Expression but Develop Normally in the Absence of T-bet

Journal of Immunology, 2020
Key Points Developing CD11c+ T-bet+ B cells require TFH1 cells that produce both IFN-γ and IL-21. Obligate IFN-γ and CD40L signals are provided at distinct times following infection.
Russell C. Levack, K. Newell, M. Popescu, Berenice Cabrera-Martinez, G. Winslow   +4 more
semanticscholar   +1 more source