Results 1 to 10 of about 26,034 (307)

Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy [PDF]

Frontiers in Immunology
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with ...
Yuqing Liu, Fan Li, Juanjuan Wang, Rongcun Yang, Rongcun Yang, Rongcun Yang   +5 more
doaj   +2 more sources

The prognostic value of the tertiary lymphoid structure in gastrointestinal cancers [PDF]

Frontiers in Immunology, 2023
BackgroundNumerous studies and research papers have provided evidence suggesting that tertiary lymphoid structures (TLS) play a crucial role in combating and suppressing tumor growth and progression.
Aoyang Yu, Menghan Cao, Kaile Zhang, Yule Yang, Luyao Ma, Xinran Zhang, Yang Zhao, Xiao Ma, Zhixiang Fan, Zhengxiang Han, Hongmei Wang   +10 more
doaj   +2 more sources

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
doaj   +1 more source

Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes

Frontiers in Immunology, 2023
BackgroundProinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME).
Lilit Karapetyan, Hassan M. AbuShukair, Aofei Li, Andrew Knight, Ayah Nedal Al Bzour, Ian P. MacFawn, Zachary J. Thompson, Ann Chen, Xi Yang, Rebekah Dadey, Arivarasan Karunamurthy, Danielle Vargas De Stefano, Cindy Sander, Sheryl R. Kunning, Yana G. Najjar, Diwakar Davar, Jason J. Luke, William Gooding, Tullia C. Bruno, Tullia C. Bruno, John M. Kirkwood, John M. Kirkwood, Walter J. Storkus, Walter J. Storkus   +23 more
doaj   +1 more source

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Frontiers in Immunology, 2021
The tumor microenvironment is a complex ecosystem almost unique to each patient. Most of available therapies target tumor cells according to their molecular characteristics, angiogenesis or immune cells involved in tumor immune-surveillance ...
Charlotte Domblides, Charlotte Domblides, Charlotte Domblides, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Clémence Riffard, Clémence Riffard, Clémence Riffard, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Véronique Mateo, Véronique Mateo, Véronique Mateo, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +27 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source

The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures

Frontiers in Immunology, 2021
Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé, Mélanie Dieudé, Mélanie Dieudé, Imane Kaci, Imane Kaci, Imane Kaci, Marie-Josée Hébert, Marie-Josée Hébert, Marie-Josée Hébert   +8 more
doaj   +1 more source

Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response.
Shota Aoyama, Ryosuke Nakagawa, James J. Mulé, James J. Mulé, Adam W. Mailloux   +4 more
doaj   +1 more source

Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)

Креативная хирургия и онкология, 2020
This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov, K. Sh. Gantsev, D. S. Tursumetov   +2 more
doaj   +1 more source

Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

Frontiers in Immunology, 2023
Pancreatic cancer (PC) is extremely malignant and shows limited response to available immunotherapies due to the hypoxic and immunosuppressive nature of its tumor microenvironment (TME). The aggregation of immune cells (B cells, T cells, dendritic cells,
Xinlei Zou, Canghai Guan, Jianjun Gao, Wujiang Shi, Yunfu Cui, Xiangyu Zhong   +5 more
doaj   +1 more source