Results 61 to 70 of about 26,034 (307)

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjorgren's syndrome? Association between clinical, histopathological, and molecular features: A retrospective study [PDF]

, 2014
Objectives: Several histological scoring systems, including the focus score, performed in minor salivary glands (MSGs) by hematoxylin-eosin (H&E) staining, have been employed in clinical practice to assess the inflammatory infiltrate and provide the ...
Alunno, A., Bartoloni, E., Berardicurti, O., Bistoni, O., Carubbi, F., Caterbi, S., CICCIA, Francesco, Cipriani, P., Di Benedetto, P., Gerli, R., Giacomelli, R., Ruscitti, P., TRIOLO, Giovanni   +12 more
core   +2 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome

Nature Communications
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial ...
Saba Nayar, Jason D. Turner, Saba Asam, Eanna Fennell, Matthew Pugh, Serena Colafrancesco, Onorina Berardicurti, Charlotte G. Smith, Joe Flint, Ana Teodosio, Valentina Iannizzotto, David H. Gardner, Joel van Roon, Ilya Korsunsky, Dawn Howdle, Roche Fibroblast Network Consortium, Andreas P. Frei, Kara G. Lassen, Simon J. Bowman, Wan-Fai Ng, Adam P. Croft, Andrew Filer, Benjamin A. Fisher, Christopher D. Buckley, Francesca Barone   +24 more
doaj   +1 more source

Regulation Of Tertiary Lymphoid Structure Formation In Periodontitis

International Dental Journal
Aim or purpose: This study investigates the role of gingival fibroblasts in the formation of tertiary lymphoid structures (TLSs) in periodontitis and their impact on inflammation.
Jiawei Lu, Zehui Xiong, Jinyi Zhang, Lijun Luo, Xiao Wu   +4 more
doaj   +1 more source

Measles virus host invasion and pathogenesis [PDF]

, 2016
Measles virus is a highly contagious negative strand RNA virus that is transmitted via the respiratory route and causes systemic disease in previously unexposed humans and non-human primates.
Duprex, W.P. (Paul), Laksono, B.M. (Brigitta), McQuaid, S. (Stephen), Swart, R.L. (Rik) de, Vries, R.D. (Rory) de   +4 more
core   +1 more source

Tertiary lymphoid structures in ovarian cancer

Frontiers in Immunology
Ovarian cancer (OC) is a significant cause of cancer-related mortality in women worldwide. Despite advances in treatment modalities, including surgery and chemotherapy, the overall prognosis for OC patients remains poor, particularly for patients with advanced or recurrent disease.
Guojuan Sun, Yi Liu
openaire   +3 more sources

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Tertiary lymphoid structures in pulmonary granulomas of cattle experimentally infected with aerosolized Mycobacterium bovis

BMC Veterinary Research
Mycobacterium bovis is the primary cause of tuberculosis in animals, most notably cattle. In cattle and other susceptible hosts, the hallmark lesion of tuberculosis is the granuloma.
Mitchell V. Palmer, Douglas E. Jones, Nicholas J. Bockenstedt, Paola M. Boggiatto   +3 more
doaj   +1 more source

The Molecular Pathology of Prion Diseases [PDF]

, 2004
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of invariably fatal neurodegenerative disorders. Uniquely, they may present as sporadic, inherited, or infectious forms, all of which involve conversion of the normal ...
Herms, Jochen, Kretzschmar, Hans A., Vassallo, Neville   +2 more
core  

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2 [PDF]

, 2017
Gab2 is a large disordered protein that regulates several cellular signalling pathways and is overexpressed in different forms of cancer. Because of its disordered nature, a detailed characterization of the mechanisms of recognition between Gab2 and ...
Bonetti, Daniela, De Simone, Alfonso, Gianni, Stefano, Toto, Angelo   +3 more
core   +3 more sources