Results 131 to 140 of about 224,987 (336)

Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease

, 2022
Kritika Singh, Upendra Rathore, Mohit Kumar Rai, Manas Ranjan Behera, Neeraj Jain, Manish Ora, Dharmendra Bhadauria, Supriya Sharma, Gaurav Pande, Sanjay Gambhir, Alok Nath, Sudeep Kumar, Aman Sharma, Vikas Agarwal, Durga Prasanna Misra   +14 more
openalex   +4 more sources

Curcumin modulates inflammatory responses in peripheral blood mononuclear cells from women with gestational diabetes mellitus

Central European Journal of Immunology
Introduction Curcumin is a multi-functional component with anti-inflammatory and immunomodulatory properties. Unregulated immune responses may be a causative factor in the development of gestational diabetes mellitus (GDM).
Zhenzhen Liu, Liu Zheng, Yao Wu, Huijuan Li, Junfang Liu   +4 more
doaj   +1 more source

Regulatory T cells enhance Th17 migration in psoriatic arthritis which is reversed by anti-TNF

, 2021
Dao X. Nguyen, Helen Baldwin, Amara Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein   +4 more
openalex   +1 more source

Role of CD19⁺CD5⁺CD1d⁺ Bregs in maintaining the Th17/Treg balance in mice with systemic lupus erythematosus complicated with atherosclerosis [PDF]

, 2023
Zhen‐Zhen Zhu, Xiao‐Huan Chen, Si‐Ru Wei, Jia Xu, Yahui Wang, Wen‐Jue Wu, Hong Liu, Hanyou Mo   +7 more
openalex   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Aquaporin 4‐specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter [PDF]

, 2012
Michel Varrin‐Doyer, Collin M. Spencer, Ulf Schulze‐Topphoff, Patricia A. Nelson, Robert M. Stroud, Bruce Cree, Scott S. Zamvil   +6 more
openalex   +1 more source

TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development [PDF]

, 2023
Honggang Sun, Qi Jiang, Wenjing Fan, Xiaojin Shen, Zhaowei Wang, Xin Wang   +5 more
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

AGE-DEPENDENT CHANGES OF T-REGULATORY AND Th17 SUBSET LEVELS IN PERIPHERAL BLOOD FROM HEALTHY HUMANS

Медицинская иммунология, 2017
Age-dependent development of Th17 and Treg lymphocyte subsets in healthy  humans is studied insufficiently. The  present  study aimed  to investigate  quantitative characteristics of Th17  and  Treg subsets in peripheral blood of healthy  subjects for ...
A. P. Toptygina, E. L. Semikina, S. V. Petrichuk, R. Sh. Zakirov, O. V. Kurbatova, E. A. Kopyltsova, Yu. А. Komakh   +6 more
doaj   +1 more source