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Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol, a plant-derived sterol, has shown anti-inflammatory effects. Our study aimed
Shuting Wen +6 more
semanticscholar +1 more source
The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story
The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota.
Hongyu Cheng +3 more
doaj +1 more source
Effects of glycodelin on CCR6+ cell subpopulations of Th17-polarized helper T cells
Glycodelins, the glycosylated proteins of reproductive tract are characterized by immunomodulatory functions, are of interest because of their role in the development of immune tolerance.
V. P. Timganova +6 more
doaj +1 more source
MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]
MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann +37 more
core +2 more sources
Salt-responsive gut commensal modulates TH17 axis and disease
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension.
N. Wilck +38 more
semanticscholar +1 more source
Wilson's disease (WD) is a rare hereditary disease caused by a deficiency of the ATF7B transporter. The accumulation of copper can cause damage to organs and cells, mainly the liver.
O. V. Kurbatova +10 more
doaj +1 more source
Retinoic acid as a modulator of T cell immunity [PDF]
Indexación: Scopus. DOAJ.Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system,
Bono, M.R. +5 more
core +1 more source
The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4 ...
Jun-bin Yan +3 more
semanticscholar +1 more source
Human Th17 cells: Are they different from murine Th17 cells? [PDF]
AbstractType 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre‐eminent cytokine of Th1 cells is IFN‐γ and that of Th2 cells is IL‐4, the distinctive cytokine of Th17 cells is IL‐17A.
ANNUNZIATO, FRANCESCO +4 more
openaire +3 more sources
MS is a common disease of the central nervous system that leads to disability and reduced quality of life. The debut of disease in 3-5% of patients occurs in childhood and has a less favorable course compared to adults.
T. V. Radygina +7 more
doaj +1 more source

