Results 41 to 50 of about 235,232 (245)

A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3

Biomolecules, 2020
Among diverse helper T-cell subsets, Th17 cells appear to be pathogenic in diverse autoimmune diseases, and thus, targeting Th17 cells could be beneficial for the treatment of the diseases in humans.
Young-Jun Park, Minkyoung Cho, Garam Choi, Hyeongjin Na, Yeonseok Chung   +4 more
doaj   +1 more source

IL-17-Producing Regulatory T lymphocytes – Suppressors or Effectors?

Учёные записки Казанского университета: Серия Естественные науки, 2023
Regulatory T (Treg) lymphocytes are a T helper population that controls the intensity of the immune response and maintains immune tolerance by selectively suppressing the activity of effector T lymphocytes.
E. M. Kuklina, N. S. Glebezdina
doaj   +1 more source

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

Journal of Experimental Medicine, 2020
Th17 cells undergo metabolic reprogramming towards glycolysis to support their differentiation and pathogenicity. Damasceno et al. report that PKM2, a glycolytic enzyme, plays a nonmetabolic role in mediating Th17 cell differentiation and autoimmune ...
L. E. Damasceno, D. Prado, F. Veras, M. Fonseca, J. Toller-Kawahisa, M. H. Rosa, G. Públio, T. V. Martins, F. Ramalho, A. Waisman, F. Cunha, T. Cunha, J. Alves-Filho   +12 more
semanticscholar   +1 more source

Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis [PDF]

Iranian Journal of Immunology, 2020
Background: T helper 17 (Th17) cells and the related cytokines, interleukin (IL)- 17 and IL-23, were proved to play pivotal roles during the development of allergic rhinitis (AR).
Hong Ouyang, Jie Cheng, Jingdong Du, Huiyun Gan, Zheng Lu   +4 more
doaj   +1 more source

Gut and Cutaneous Microbiome Featuring Abundance of Lactobacillus reuteri Protected Against Psoriasis-Like Inflammation in Mice

Journal of Inflammation Research, 2021
Hui-Ling Chen,1,2,* Yi-Bin Zeng,3,* Zheng-Yan Zhang,1,2,* Chao-Yue Kong,1,2 Shi-Long Zhang,1,2 Zhan-Ming Li,1,2 Jia-Ting Huang,1,2 Ya-Yun Xu,1,2 Yu-Qin Mao,1,2 Pei-Ran Cai,1,2 Bing Han,1,2 Wu-Qing Wang,3 Li-Shun Wang1,2 1Center for ...
Chen HL, Zeng YB, Zhang ZY, Kong CY, Zhang SL, Li ZM, Huang JT, Xu YY, Mao Y, Cai PR, Han B, Wang WQ, Wang LS   +12 more
doaj  

Decreased TLR4 expression on monocytes may cause regulatory T cells abnormality in patients with primary immune thrombocytopenia

Autoimmunity, 2017
Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions including T helper type 1 cell (Th1) polarization and regulatory T cells (Tregs) deficiency.
Yating Hao, Huiyuan Li, Yang Li, Mingen Lyu, Donglei Zhang, Rongfeng Fu, Yue Guan, Shixuan Wang, Boyang Sun, Xueqing Dou, Renchi Yang   +10 more
doaj   +1 more source

T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus

Frontiers in Immunology, 2020
The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development of organ inflammation in systemic lupus erythematosus (SLE).
J. Shan, Hong Jin, Yan Xu
semanticscholar   +1 more source

Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury [PDF]

, 2019
We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates in the activation of Th17 cells and influences renal injury. In rats, following renal ischemia/reperfusion (I/R), there was a rapid and sustained influx of Orai1 ...
Basile, David P., Mehrotra, Purvi, Neyra, Javier A., Sturek, Michael   +3 more
core   +1 more source

Altered peripheral blood Th17 and follicular T-helper subsets in patients with pulmonary tuberculosis

Инфекция и иммунитет, 2019
Tuberculosis (TB) is one of the most common infections worldwide. Eradication of an intracellular pathogen M. tuberculosis requires to induce a Th1 response by activating IFNγ-producing tissue macrophages.
I. V. Kudryavtsev, M. K Serebriakova, A. A. Starshinova, Yu. S. Zinchenko, N. Yu. Basantsova, E. N. Belyaeva, M. V. Pavlova, P. K. Yablonskiy   +7 more
doaj   +1 more source

Phenotypic and functional features of human Th17 cells

Journal of Experimental Medicine, 2007
T helper (Th) 17 cells represent a novel subset of CD4+ T cells that are protective against extracellular microbes, but are responsible for autoimmune disorders in mice. However, their properties in humans are only partially known.
F. Annunziato, L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, B. Mazzinghi, E. Parente, L. Filì, S. Ferri, Francesca Frosali, F. Giudici, P. Romagnani, P. Parronchi, F. Tonelli, E. Maggi, S. Romagnani   +15 more
semanticscholar   +1 more source