Российский кардиологический журнал, 2022 Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods.
A. Yu. Filatova +6 more
doaj +1 more source
TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. [PDF]
, 2013 Our gastrointestinal tract is a portal of entry for a number of bacteria and viruses. Thus, this tissue must develop ways to induce antigen-specific T cell and antibody responses quickly.
DePaolo, R William +5 more
core +1 more source
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation
Journal of Experimental Medicine, 2020 Th17 cells undergo metabolic reprogramming towards glycolysis to support their differentiation and pathogenicity. Damasceno et al. report that PKM2, a glycolytic enzyme, plays a nonmetabolic role in mediating Th17 cell differentiation and autoimmune ...
L. E. Damasceno +12 more
semanticscholar +1 more source
Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease
European Journal of Immunology, 2021 Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive immune responses, antagonizing each other in immune disorders. Th17/Treg balance is critical to maintaining the immune homeostasis of human bodies and is tightly
Weiqi Zhang +6 more
semanticscholar +1 more source
Erythropoietin inhibits SGK1-dependent Th17 cell induction and Th17 cell–dependent kidney disease [PDF]
JCI Insight, 2019 IL-17-producing CD4+ cells (TH17) are pathogenically linked to autoimmunity including to autoimmune kidney disease. Erythropoietin's (EPO) newly recognized immunoregulatory functions and its predominant intra-renal source suggested that EPO physiologically regulates TH17 differentiation, thereby serving as a barrier to the development of autoimmune ...
Chiara Donadei +13 more
openaire +4 more sources
Autoimmunity, 2017 Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions including T helper type 1 cell (Th1) polarization and regulatory T cells (Tregs) deficiency.
Yating Hao +10 more
doaj +1 more source
Immunological considerations in the development of Pseudomonas aeruginosa vaccines
Human Vaccines & Immunotherapeutics, 2020 Pseudomonas aeruginosa is an opportunistic human pathogen capable of causing a wide range of potentially life-threatening infections. With multidrug-resistant P.
Sarah M. Baker +2 more
doaj +1 more source
Persistent effects of early infant diet and associated microbiota on the juvenile immune system. [PDF]
, 2015 Early infant diet has significant impacts on the gut microbiota and developing immune system. We previously showed that breast-fed and formula-fed rhesus macaques develop significantly different gut microbial communities, which in turn are associated ...
Ardeshir, Amir +5 more
core +1 more source
Phenotypic and functional features of human Th17 cells
Journal of Experimental Medicine, 2007 T helper (Th) 17 cells represent a novel subset of CD4+ T cells that are protective against extracellular microbes, but are responsible for autoimmune disorders in mice. However, their properties in humans are only partially known.
F. Annunziato +15 more
semanticscholar +1 more source
Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]
, 2010 Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert +11 more
core +3 more sources