Results 81 to 90 of about 235,232 (245)
Science Translational Medicine, 2018 Combined patient and animal model studies implicate microbiota-triggered TH17 cells as disease drivers and therapeutic targets in periodontitis. Probing periodontitis pathology Periodontitis is a common inflammatory disease that can lead to bone loss ...
N. Dutzan +18 more
semanticscholar +1 more source
Science immunology, 2020 Ongoing classic IL-6 receptor signaling is required to maintain the TH17 program, acting upstream of IL-23 to sustain RORγt expression. TH17 sustenance via IL-6 The pathogenic role of the TH17 subset of CD4+ T cells in multiple immune-mediated diseases ...
Stacey N. Harbour +9 more
semanticscholar +1 more source
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4. [PDF]
, 2017 While it is recognized that aquaporin-4 (AQP4)-specific T cells and antibodies participate in the pathogenesis of neuromyelitis optica (NMO), a human central nervous system (CNS) autoimmune demyelinating disease, creation of an AQP4-targeted model with ...
Cruz-Herranz, Andrés +7 more
core +1 more source
B cell contribution of the CD4+ T cell inflammatory phenotypes in systemic lupus erythematosus
Autoimmunity, 2017 Systemic lupus erythematosus is an autoimmune disease in which the effector molecules responsible for tissue damage are antibodies directed against a large number of self-antigens, among which nucleic acids complexed with proteins play a prominent role ...
Seung-Chul Choi, Laurence Morel
doaj +1 more source
Expression of the RUNX family in skin lesions from patients with psoriasis vulgaris
Pifu-xingbing zhenliaoxue zazhi, 2022 Objective To explore the expression and distribution of runt-related transcription factor (RUNX) family in lesions of psoriasis vulgaris (PV), and analyze the correlation between its levels and markers of proliferation, apoptosis and immunity.
Dan HONG +4 more
doaj +1 more source
Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]
, 2017 Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S +5 more
core +1 more source
Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease
Autoimmunity, 2018 The prognosis of autoimmune thyroid disease (AITD) including Graves’ disease (GD) and Hashimoto’s disease (HD) is difficult to predict. We previously suggested that Th17 cells may be associated with the pathogenesis of AITD.
Takayuki Kunisato +12 more
doaj +1 more source
Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease [PDF]
arXiv, 2013 Acute Respiratory Distress Syndrome (ARDS) is a very severe syndrome leading to respiratory failure and subsequent mortality. Sepsis is one of the leading causes of ARDS. Thus, extracellular bacteria play an important role in the pathophysiology of ARDS. Overactivated neutrophils are the major effector cells in ARDS.
arxiv
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. [PDF]
, 2016 BackgroundOur previous studies showed that the non-psychoactive cannabinoid, cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis model of multiple ...
Coppola, Giovanni +5 more
core +2 more sources
Clinical, Cosmetic and Investigational Dermatology, 2023 Feng Hu,1,2,* Zilu Qu,1,2,* Kai Chen,1,2 Ping Zhang,1 Bei Wang,1 Ruili Jiang,1 Yuyue Zuo,1 Ping Xia,1,* Hongxiang Chen3,4,* 1Department of Dermatology, Wuhan No.
Hu F +8 more
doaj