Results 81 to 90 of about 44,050 (359)

Vergleich der Dissoziationskonstanten von 2-Amino-thiazol- und 2-Amino-oxazol-Derivaten

CHIMIA, 1973
A description is given for the synthesis by standard methods of 2-Amino-4-phenyl- and 2-Amino-5-phenyl-thiazoles having different para-substituents together with the 2-Amino-4-phenyl-oxazole analogues. The pKa-values were determined for the compounds in
U. Stauss, H.P. Härter, O. Schindler
doaj   +1 more source

The structure–activity relationship and computational studies of 1,3-thiazole derivatives as cholinesterase inhibitors with anti-inflammatory activity

Comptes Rendus. Chimie, 2022
In our previous research, some screened 1,3-thiazole fragments were found to be potent by inhibiting LPS-induced TNF$\alpha $ and IL-8 release with IC50 values in the $\mu $M range without cytotoxic activity.
Modrić, Marina, Božičević, Marin, Odak, Ilijana, Talić, Stanislava, Barić, Danijela, Mlakić, Milena, Raspudić, Anamarija, Škorić, Irena   +7 more
doaj   +1 more source

Efficient synthesis of biazoles by aerobic oxidative homocoupling of azoles catalyzed by a copper(I)/2-pyridonate catalytic system. [PDF]

, 2011
A highly efficient and convenient CuCl/2-pyridonate catalytic system for oxidative homocoupling of azoles affording a biazole product has been developed.
Fujita, Ken-ichi, Yamaguchi, Ryohei, Zhu, Mingwen   +2 more
core   +1 more source

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry

Scientia Pharmaceutica, 2018
This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry
Anna Kryshchyshyn, O. Roman, A. Lozynskyi, R. Lesyk   +3 more
semanticscholar   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Synthesis, Characterization and Bioassay of Novel Substituted 1-(3-(1,3-Thiazol-2-yl)phenyl)-5-oxopyrrolidines

Molecules, 2020
Thiazole derivatives attract the attention of scientists both in the field of organic synthesis and bioactivity research due to their high biological activity.
Birutė Sapijanskaitė-Banevič, Božena Šovkovaja, Rita Vaickelionienė, Jūratė Šiugždaitė, Eglė Mickevičiūtė   +4 more
doaj   +1 more source

InCl3-​assisted synthesis and cytotoxic studies of some novel heteroaryl thiazoles [PDF]

, 2013
Heteroaryl thiazoles were synthesized by the Hantzsch reaction of various α-​bromoketones with aryl thioureas using InCl3 as a catalyst in a shorter reaction time. The synthesized compds.
Boggavarapu Chand, S.G., Boregowda Puttaraju, K., Kalegowda Shivashankar, ., Ramamohan Reddy, K., Rasal Vijaykumar, P., Venkata Vivek, P.N.   +5 more
core  

Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study

Medicinal Chemistry Research, 2018
Synthesis and investigation of antifungal, anticonvulsant and anti-Toxoplasma gondii activities of ten novel (2-(cyclopropylmethylidene)hydrazinyl)thiazole 3a–3j are presented.
Krzysztof Z Łączkowski, Natalia Konklewska, Anna Biernasiuk, A. Malm, K. Sałat, A. Furgala, K. Dzitko, A. Bekier, Angelika Baranowska-Łączkowska, Agata Paneth   +9 more
semanticscholar   +1 more source

CO2‐DBU‐Triggered Photoredox‐Catalyzed Direct α‐C‐H Alkylation of Alcohols

Advanced Science, EarlyView.
An efficient photoinduced and metal‐free method is developed for direct α‐C–H monoalkylation of alcohols utilizing the CO2‐DBU system as the hydrogen bond acceptor (HBA) in the presence of H2O, allowing for selective functionalization of alcohols with a broad substrate scope.
Zeyu Zhang, Zongchang Han, Yuhao Shang, Han‐Shi Hu, Jun Li, Chanjuan Xi   +5 more
wiley   +1 more source

Neuere heterocyclische Zwischenprodukte für die Azokupplung durch Cyclisierung von Nitrilen

CHIMIA, 1980
Two types of syntheses of heteroaromatic amines by cyclization of nitriles are described. It is dealt with the cyclization of nitriles by elemental sulphur yielding thiophenes and thiazoles and with some reactions of the resulting 2-amino-thiophene-3 ...
Karl Gewald
doaj   +1 more source