Results 1 to 10 of about 196,590 (178)
PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation [PDF]
Nature CommunicationsTight junctions are crucial for maintaining intestinal barrier homeostasis, but how organisms modulate these junctions remain unclear. Here, we show a role for PEAK1 at cell-cell contact sites, where it interacts with ZO-1 via a conserved region spanning
Zaikuan Zhang +12 more
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Claudins in lung diseases [PDF]
Respiratory Research, 2011 Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions.
Soini Ylermi
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Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2017 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
Ali Shawki, Declan F. McCole
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The role of ZEB1 in regulating tight junctions in antrochoanal polyp [PDF]
HeliyonBackground: Antrochoanal polyp (ACP) is a benign nasal mass of unknown etiology. Tight junctions (TJs) are essential to the epithelial barrier that protects the body from external damage.
Yisha Wu +7 more
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Stinging Tight Junctions With WASPs [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2018 Benjamin Aroeti, PhD +1 more
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Editorial: Regulation of permeability of tight junctions [PDF]
Frontiers in Cell and Developmental BiologyClaudia Tanja Mierke
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Molecules, 2021 Glaesserella parasuis (G. parasuis) causes inflammation and damage to piglets. Whether polyserositis caused by G. parasuis is due to tight junctions damage and the protective effect of baicalin on it have not been examined.
Jiacheng Zhang +7 more
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Nanoscale segregation of channel and barrier claudins enables paracellular ion flux
Nature Communications, 2022 Meshworks of claudin polymers control the paracellular transport and barrier properties of epithelial tight junctions. Here, the authors show different claudin nanoscale organization principles, finding that claudin segregation enables barrier formation ...
Hannes Gonschior +10 more
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Microorganisms, 2023 Extracellular glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has multiple interactions with various gut epithelial components. For instance, GAPDH in Lactobacillus johnsonii MG cells interacts with junctional adhesion molecule-2 (JAM-2) in Caco-2 cells
Mengying Lyu +4 more
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Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the
Li Zuo, Wei-Ting Kuo, Jerrold R. Turner
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