Loss of tricellular tight junction tricellulin leads to hyposalivation in Sjögren’s syndrome [PDF]
International Journal of Oral ScienceTricellulin, a key tricellular tight junction (TJ) protein, is essential for maintaining the barrier integrity of acinar epithelia against macromolecular passage in salivary glands.
Xiangdi Mao +9 more
doaj +4 more sources
Tricellulin facilitates colorectal cancer metastasis through activation of the TGFβ/SMAD2/3 signalling pathway [PDF]
Frontiers in OncologyBackgroundTricellulin belongs to the TAMP family of proteins and is primarily localized at the tricellular tight junctions. While its role in the progression of cancer has been reported, its importance in the progression of colorectal cancer (CRC ...
Wenfang Yang +7 more
doaj +2 more sources
Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells [PDF]
Frontiers in Pharmacology, 2023 The oleoresin myrrh has been used for centuries as an anti-inflammatory remedy for a variety of diseases and is said to have a protective effect on the intestinal epithelium.
Helena Hader +4 more
doaj +2 more sources
Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1 [PDF]
Cells, 2023 Background: In patients with diarrhea-predominant irritable bowel syndrome (IBS-D), the diarrheal mechanisms are largely unknown, and they were examined in this study on colon biopsies.
Karem Awad +7 more
doaj +2 more sources
Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder [PDF]
European Psychiatry, 2023 Introduction Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders.
H. Ferahkaya +3 more
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A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins [PDF]
Toxins, 2023 Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and the molecular ...
Martina Schneemann +9 more
doaj +2 more sources
Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis [PDF]
BMC Gastroenterology, 2021 Background Ulcerative colitis (UC) has a relapsing and remitting pattern, wherein the underlying mechanisms of the relapse might involve an enhanced uptake of luminal antigens which stimulate the immune response.
Jia-Chen E. Hu +6 more
doaj +2 more sources
Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M) [PDF]
Cells, 2023 Background: The underlying pathophysiology of irritable bowel syndrome (IBS) is still unclear. Our aim was to investigate the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type IBS (IBS-M).
Karem Awad +7 more
doaj +2 more sources
Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family [PDF]
BMC Cell Biology, 2009 Background Tight junctions are an intercellular adhesion complex of epithelial and endothelial cells, and form a paracellular barrier that restricts the diffusion of solutes on the basis of size and charge.
Balda Maria S +3 more
doaj +4 more sources
CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers [PDF]
Toxins, 2023 Background: Clostridioides difficile binary toxin (CDT) defines the hypervirulence of strains in nosocomial antibiotic-induced colitis with the highest mortality.
Lucas Heils +4 more
doaj +2 more sources