Novel compound heterozygous variants in MARVELD2 causing autosomal recessive hearing loss in two Chinese families [PDF]
Molecular Genetics & Genomic MedicineBackground Hereditary hearing loss is an important component of congenital hearing loss. MARVELD2 (OMIM ID:610572), located in the DFNB49 locus, which encodes a tight junction protein tricellulin playing an important role in the sensory epithelial ...
Xinyu Shi +4 more
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Contribution of the tricellular tight junction proteins, tricellulin and angulin-1, to paracellular water permeability [PDF]
Journal of Cell Biology, 2021 In epithelia, large amounts of water pass by transcellular and paracellular pathways, driven by the osmotic gradient built up by solutes’ movement.
Ayala Torres, Carlos Mario
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Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin [PDF]
Particle and Fibre Toxicology, 2020 Background While exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little attention has been paid to their effects on the airway epithelial barrier.
Timothy Smyth +5 more
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Case report: A novel nonsense mutation in the MARVELD2 gene causes nonsyndromic hearing loss in a China family [PDF]
Frontiers in GeneticsThe MARVELD2 gene is located on chromosome 5q13.2 and is associated with autosomal recessive nonsyndromic hearing loss (OMIM: # 610572). In this study, we identified and reported a novel nonsense mutation in MARVELD2 c.
Chuican Huang +11 more
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Apoptotic Fragmentation of Tricellulin [PDF]
International Journal of Molecular Sciences, 2019 Apoptotic extrusion of cells from epithelial cell layers is of central importance for epithelial homeostasis. As a prerequisite cell–cell contacts between apoptotic cells and their neighbors have to be dissociated. Tricellular tight junctions (tTJs)
Huber, Otmar +3 more
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Wharton’s jelly mesenchymal stem cells attenuate global hypoxia-induced learning and memory impairment via preventing blood-brain barrier breakdown [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Intracerebroventricular (ICV) injections of mesenchymal stem cells (MSCs) may improve the function and structure of blood-brain barrier (BBB), possibly by preserving the BBB integrity.
Tahmineh Mokhtari +4 more
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Tubuloside B ameliorates blood-brain barrier disruption and cognitive deficits after cerebral ischemia by inhibiting TRIC protein ubiquitination and degradation [PDF]
Journal of NeuroinflammationBackground and purpose Vascular cognitive impairment (VCI) is strongly linked to blood-brain barrier (BBB) dysfunction. This study investigated whether Tubuloside B (Tub-B), a primary bioactive compound of Cistanche tubulosa, ameliorates cognitive ...
Mingli He +8 more
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Restoration of colonic barrier function by tofacitinib in experimental colitis: anti-inflammatory effects and decreased expression of claudins-2 and claudin-15 [PDF]
Intestinal ResearchBackground/Aims Inflammatory bowel disease can be triggered by disturbances in intestinal mucosal integrity, leading to bacterial transmigration. The treatment of inflammatory bowel diseases must not only aim to reduce inflammation, but also to reverse ...
Humberto Barbosa da Costa Filho +7 more
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Looking at tricellulin expression in the brain [PDF]
, 2010 Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010It was recently reported the existence of a protein, called tricellulin (TRIC), concentrated at tricellular tight junctions (TJ) but also ...
Mariano, Cibelle Neiva Cavalcanti, 1984-
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Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells [PDF]
Biology Open, 2014 Occludin is the first identified protein in the tight junction (TJ), but its function has remained for the most part obscure. TJs have been demonstrated to play important roles in the inner ear function, and occludin is expressed in all the epithelial ...
Shin-ichiro Kitajiri +5 more
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