Results 31 to 40 of about 2,567 (176)

Tricellulin Is a Tight-Junction Protein Necessary for Hearing [PDF]

The American Journal of Human Genetics, 2006
The inner ear has fluid-filled compartments of different ionic compositions, including the endolymphatic and perilymphatic spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. TRIC encodes tricellulin, a recently discovered tight-junction (TJ) protein that contributes to the structure and ...
Riazuddin, Saima, Ahmed, Zubair M., Fanning, Alan S., Lagziel, Ayala, Kitajiri, Shin-ichiro, Ramzan, Khushnooda, Khan, Shaheen N., Chattaraj, Parna, Friedman, Penelope L., Anderson, James M., Belyantseva, Inna A., Forge, Andrew, Riazuddin, Sheikh, Friedman, Thomas B.   +13 more
openaire   +2 more sources

Downsloping high-frequency hearing loss due to inner ear tricellular tight junction disruption by a novel ILDR1 mutation in the Ig-like domain. [PDF]

PLoS ONE, 2015
The immunoglobulin (Ig)-like domain containing receptor 1 (ILDR1) gene encodes angulin-2/ILDR1, a recently discovered tight junction protein, which forms tricellular tight junction (tTJ) structures with tricellulin and lipolysis-stimulated lipoprotein ...
Nayoung K D Kim, Tomohito Higashi, Kyoung Yeul Lee, Ah Reum Kim, Shin-ichiro Kitajiri, Min Young Kim, Mun Young Chang, Veronica Kim, Seung-Ha Oh, Dongsup Kim, Mikio Furuse, Woong-Yang Park, Byung Yoon Choi   +12 more
doaj   +1 more source

The endothelium permeability after bioresorbable scaffolds implantation caused by the heterogeneous expression of tight junction proteins

Materials Today Bio, 2022
As one of the main functions of vascular endothelial cells, Vascular permeability is determined by four tight junction proteins (TJPs): Zonula Occludens-1 (ZO-1), Claudin-5, Occludin and Tricellulin.
Junyang Huang, Shuang Ge, Desha Luo, Ruolin Du, Yang Wang, Wanling Liu, Guixue Wang, Tieying Yin   +7 more
doaj   +1 more source

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]

, 2019
Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland, Fromm, Anja, Fromm, Michael, Gorkiewicz, Gregor, Hering, Nina A., Högenauer, Christoph, Schulzke, Jörg-Dieter, Troeger, Hanno, Zechner, Ellen   +8 more
core   +1 more source

siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model

Molecular Therapy: Methods & Clinical Development, 2021
Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment.
Paul S. Cassidy, Ruth A. Kelly, Ester Reina-Torres, Joseph M. Sherwood, Marian M. Humphries, Anna-Sophia Kiang, G. Jane Farrar, Colm O’Brien, Matthew Campbell, W. Daniel Stamer, Darryl R. Overby, Pete Humphries, Jeffrey O’Callaghan   +12 more
doaj   +1 more source

LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. [PDF]

, 2015
The blood-brain barrier (BBB) is a term used to describe the unique properties of central nervous system (CNS) blood vessels. One important BBB property is the formation of a paracellular barrier made by tight junctions (TJs) between CNS endothelial ...
Arnold, Thomas D, Daneman, Richard, Derugin, Nikita, Lee, Seo Yeon, Lin, Christina, Munji, Roeben N, Ruderisch, Nadine, Sohet, Fabien, Soung, Allison, Vexler, Zinaida S, Yen, Frances T   +10 more
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A novel pathogenic variant in the MARVELD2 gene causes autosomal recessive non-syndromic hearing loss in an Iranian family [PDF]

, 2018
BACKGROUND AND AIMS: Hearing loss (HL) is the most common sensorineural disorder and one of the most common human defects. HL can be classified according to main criteria, including: the site (conductive, sensorineural and mixed), onset (pre-lingual ...
Hashemzadeh-Chaleshtori, Morteza, Mohammadi-Asl, Javad, Nemati-Zargaran, Fatemeh, Saki, Nader, Tabatabaiefar, Mohammad Amin, Taghipour-Sheshdeh, Afsaneh, Tahmasebi, Parisa, Zarepour, Narges   +7 more
core   +1 more source

Tricellulin deficiency affects tight junction architecture and cochlear hair cells [PDF]

Journal of Clinical Investigation, 2013
The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (also known as MARVELD2), which encodes a tricellular tight junction protein known as tricellulin, lead to nonsyndromic hearing loss (DFNB49).
Gowri, Nayak, Sue I, Lee, Rizwan, Yousaf, Stephanie E, Edelmann, Claire, Trincot, Christina M, Van Itallie, Ghanshyam P, Sinha, Maria, Rafeeq, Sherri M, Jones, Inna A, Belyantseva, James M, Anderson, Andrew, Forge, Gregory I, Frolenkov, Saima, Riazuddin   +13 more
openaire   +2 more sources

Tight junctions as regulators of tissue remodelling [PDF]

, 2016
Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions.
Balda, MS, Matter, K
core   +1 more source

Tricellulin in Crohn's disease and ulcerative colitis

The FASEB Journal, 2010
The tight junction (TJ) protein tricellulina (TRIC) is predominantly located in tricellular TJs (tTJ), the meeting points of three cells. There it forms a barrier to macromolecules without affecting ion permeability. However, at low TRIC levels the tTJ forms a pathway for macromolecules.
Susanne M Krug, Christian Bojarski, Anja Fromm, Jörg Dieter Schulzke, Michael Fromm   +4 more
openaire   +1 more source