Results 61 to 70 of about 2,567 (176)

Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin

Journal of Cell Biology, 2022
The epithelial cell sheet functions as a barrier to prevent invasion of pathogens. It is necessary to eliminate intercellular gaps not only at bicellular junctions, but also at tricellular contacts, where three cells meet, to maintain epithelial barrier function. To that end, tight junctions between adjacent cells must associate as closely as possible,
Yuma Cho, Daichi Haraguchi, Kenta Shigetomi, Kenji Matsuzawa, Seiichi Uchida, Junichi Ikenouchi   +5 more
openaire   +2 more sources

Mechanistic study on Tricellulin regulation of colorectal cancer cell invasion, metastasis and epithelial-mesenchymal transition

结直肠肛门外科
[Objectives] To investigate the related molecular mechanisms by which Tricellulin regulates the invasion, migration and metastasis and epithelial-mesenchymal transition (EMT) progression in colorectal cancer. [Methods] Tissue specimens from 40 colorectal
Yang Wenfang, Liao Cun, Zhang Jinxiu, Cheng Ruoxi, Pan Xiaoping, Chen Qiuling, Tan Yanlin, Feng Kaoyan, Qin Mengbin, Huang Jie’an   +9 more
doaj   +1 more source

Air Pollution‐Induced Epigenetic Regulation in Respiratory Diseases: Mechanisms, Dysregulation, and Therapeutic Opportunities

MedComm – Future Medicine, Volume 4, Issue 4, December 2025.
Air pollution, a major global health hazard, contributes to asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer via four core epigenetic pathways (DNA/RNA methylation, noncoding RNAs, and histone modifications), shaping gene expression and driving disease pathogenesis.
Ruitong Zeng, Jiliu Liu, Guoping Li, Junyi Wang, Anying Xiong, Ying Xiong, Xiang He   +6 more
wiley   +1 more source

Tricellulin Is Expressed in Autotypic Tight Junctions of Peripheral Myelinating Schwann Cells [PDF]

Journal of Histochemistry & Cytochemistry, 2010
Autotypic tight junctions are formed by tight junction-like structures in three regions of myelinating Schwann cells, the paranodal loops, Schmidt–Lanterman incisures, and outer/inner mesaxons, and various tight junction molecules, including claudin-19 and junctional adhesion molecule (JAM)-C.
Shin, Kikuchi, Takafumi, Ninomiya, Haruyuki, Tatsumi, Norimasa, Sawada, Takashi, Kojima   +4 more
openaire   +3 more sources

Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease [PDF]

, 2016
Genes that showed greater than four-fold upregulation in IBD.
Alfa Hc Bai, Huiling Wang, Ji-Fan Hu, Jun Yu, Kang Chao, Manying Li, Minhu Chen, Qiao Yu, Shenghong Zhang, Siew Chien Ng, Yi Cui   +10 more
core   +6 more sources

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]

, 2019
Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara, Bouchaud, Grégory, Costa, Ana, Denery-Papini, Sandra, Díaz-Perales, Araceli, E.M. Willemsen, Linette, Garrido-Arandia, María, Gavrovic-Jankulovic, Marija, H.M. van Bilsen, Jolanda, Hayen, Simone, L. Bavaro, Simona, L. Roggen, Erwin, Lozano-Ojalvo, Daniel, M. Antunes, Célia, Wróblewska, Mónica   +14 more
core   +1 more source

Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten‐Induced Cytotoxicity and Inflammation

Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.
Celiac disease (CD) is triggered by gluten in genetically predisposed individuals and is mainly treated with a gluten‐free diet. However, symptoms may persist. This review explores how certain Bifidobacterium strains may reduce inflammation and gluten toxicity through six mechanisms, including modulation of immune responses and gut microbiota.
Taynara Cipriano Scherer, Ivan De Marco, Natália Regina Coldebella Ferreira, Tatiana Colombo Pimentel, Marciane Magnani, Guilherme de Souza Hassemer, Amanda Bagolin do Nascimento, Silvani Verruck   +7 more
wiley   +1 more source

Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni [PDF]

, 2019
Campylobacter jejuni (C. jejuni) is the most common cause of foodborne gastroenteritis worldwide. The bacteria induce diarrhea and inflammation by invading the intestinal epithelium. Curcumin is a natural polyphenol from turmeric rhizome of Curcuma longa,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Golz, Julia C., Heimesaat, Markus M., Kehrenberg, Corinna, Kittler, Sophie, Lobo de Sá, Fábia Daniela, Moos, Verena, Mousavi, Soraya, Nattramilarasu, Praveen Kumar, Schulzke, Jörg-Dieter, Seinige, Diana, Stingl, Kerstin   +14 more
core   +1 more source

Tricellulin Expression and its Deletion Effects in the Endolymphatic Sac

The Journal of International Advanced Otology, 2019
Abstract   OBJECTIVES: Tricellulin is a tight junction (TJ)-forming protein that participates in the sealing function of tricellular TJs. Tricellulin-knockout (Tric−/−) mice show progressive hearing loss with degeneration of hair cells in the cochlea without physiological or physical disorders.
Ai, Matsubara, Takenori, Miyashita, Ryuhei, Inamoto, Hirofumi, Sakaguchi, Toru, Kamitani, Nozomu, Mori, Hiroshi, Hoshikawa   +6 more
openaire   +2 more sources

Lipolysis‐Stimulated Lipoprotein Receptor Gene Variants as a Cause of Progressive Familial Intrahepatic Cholestasis: A Case Report

Hepatology Research, Volume 55, Issue 11, Page 1551-1556, November 2025.
This article talks about a rare genetic condition called LSR deficiency, which causes liver issues such as another condition called PFIC. It describes the case of a 4‐year‐old girl who had yellowing of the skin, slow growth, and liver problems and was diagnosed with LSR deficiency through genetic testing. The study suggests that LSR could be a new type
Yugo Takaki, Shuichiro Umetsu, Yoshihiko Sugino, Takahiro Yamashita, Takehiko Doi, Kazuo Imagawa, Shogo Ito, Yutaro Mihara, Hisamitsu Hayashi, Ayano Inui   +9 more
wiley   +1 more source