Results 61 to 70 of about 85,493 (199)

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

A life dedicated to pharmacy [PDF]

, 2015
The Synapse meets Mary Ann Sant Fournier presently President of the Malta Chamber of Pharmacists, and visiting Senior Lecturer at the Faculty of Medicine & Surgery, UOM.peer ...
Sant Fournier, Mary Ann, The Synapse
core  

Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch, Jakob Johann Schmidt, Daniel Delev, Roland Coras, Ingmar Blümcke, Ruth Beckervordersandforth   +5 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration [PDF]

, 2018
Configuration of tripartite synapses, comprising the pre-, post-, and peri-synaptic components (axon terminal or bouton, dendritic spine, and astroglial terminal process), is a critical determinant of neurotransmitter kinetics and hence synaptic ...
Manabu Abe, Maya Yamazaki, Ageta-Ishihara, Natsumi, Abe, Manabu, Masahiko Watanabe, Watanabe, Masahiko, Yamazaki, Maya, Natsumi Ageta-Ishihara, Makoto Kinoshita, Kinoshita, Makoto, Konno, Kohtarou, Sakimura, Kenji, Kohtarou Konno, Kenji Sakimura   +13 more
core   +1 more source

Astrocyte-Mediated Neuronal Irregularities and Dynamics: The Complexity of the Tripartite Synapse

Biological Cybernetics, 2023
Abstract Despite significant advancements in recent decades, gaining a comprehensive understanding of brain computations remains a significant challenge in neuroscience. Using computational models is crucial for unraveling this complex phenomenon and is equally indispensable for studying neurological disorders.
Den Whilrex Garcia, Sabir Jacquir
openaire   +3 more sources

A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate

Frontiers in Computational Neuroscience, 2020
Recent research in neuroscience indicates the importance of tripartite synapses and gliotransmission mediated by astrocytes in neuronal system modulation.
Kerstin Lenk, Eero Satuvuori, Eero Satuvuori, Eero Satuvuori, Eero Satuvuori, Jules Lallouette, Jules Lallouette, Antonio Ladrón-de-Guevara, Hugues Berry, Hugues Berry, Jari A. K. Hyttinen   +10 more
doaj   +1 more source

Long‐Term Blood Pressure Variability, Hippocampal Subfield Volume and Cognitive Decline: A Population‐Based Prospective MRI Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Long‐term blood pressure variability (BPV) is associated with cognitive decline, yet the underlying mechanisms have not been fully elucidated. Purpose To investigate the associations between long‐term BPV and hippocampal subfield volume and cognitive function and to assess the mediation effect of hippocampal subfield volume.
Fei Li, Jing Chen, Huijing Shi, Ling Yang, Xianyu Zhu, Rui Li, Xinyu Zhao, Xiaoliang Liang, Shun Zhang, Yaping Zhang, Han Lv, Jing Li, Shuohua Chen, Yuntao Wu, Ying Hui, Shouling Wu, Zhenchang Wang, Xiaoshuai Li   +17 more
wiley   +1 more source

A Power-Efficient Neuromorphic Digital Implementation of Neural–Glial Interactions

Journal of Low Power Electronics and Applications, 2023
Throughout the last decades, neuromorphic circuits have incited the interest of scientists, as they are potentially a powerful tool for the treatment of neurological diseases.
Angeliki Bicaku, Maria Sapounaki, Athanasios Kakarountas, Sotiris K. Tasoulis   +3 more
doaj   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source