Results 81 to 90 of about 85,493 (199)

Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis

Frontiers in Physiology, 2015
Metabolic syndrome (MS) is characterized by the following physiological alterations: increase in abdominal fat, insulin resistance, high concentration of triglycerides, low levels of HDL, high blood pressure and a generalized inflammatory state.
RODRIGO eDEL RIO, Rodrigo eQuintanilla, Juan Andres Orellana, Mauricio Antonio Retamal   +3 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Automated analysis of neuronal morphology, synapse number and synaptic recruitment [PDF]

, 2011
peer reviewedThe shape, structure and connectivity of nerve cells are important aspects of neuronal function. Genetic and epigenetic factors that alter neuronal morphology or synaptic localization of pre- and post-synaptic proteins contribute ...
de Bruijn, P., Hjorth, J. J. Johannes, Susanne Eijgenraam, Ooyen, A. van, Hjorth, J.J. Johannes, Bruijn, P. de, Eijgenraam, Susanne, Sabine K. Schmitz, Wouter Veldkamp, van Ooyen, A., Arjen van Ooyen, Veldkamp, W., Hjorth, J.J.J., Christina Georgiou, Joemai, R.M.S., Wijntjes, Rick, van Ooyen, Arjen, Eijgenraam, S., Toonen, R.F.; id_orcid, Verhage, Matthijs, de Jong, A.P.H., Toonen, R.F., Georgiou, C., Jong, A.P.H. de, Veldkamp, W.J.H., Joemai, Raoul M.S., de Jong, Arthur P. H., SCHMITZ, Sabine, Joemai, Raoul M. S., Veldkamp, Wouter, Petra de Bruijn, L. Niels Cornelisse, Ruud F. Toonen, Toonen, Ruud F., Schmitz, Sabine K., Schmitz, S.K., Cornelisse, L.N., J.J. Johannes Hjorth, Verhage, M., Georgiou, Christina, Raoul M.S. Joemai, Wijntjes, R., Matthijs Verhage, Cornelisse, L. Niels, de Bruijn, Petra, Rick Wijntjes, Arthur P.H. de Jong, Veldkamp, Wouter J. H., de Jong, Arthur P.H.   +48 more
core   +1 more source

Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity

Frontiers in Cellular Neuroscience, 2019
Glutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate ...
Joana Gonçalves-Ribeiro, Joana Gonçalves-Ribeiro, Carolina Campos Pina, Carolina Campos Pina, Ana Maria Sebastião, Ana Maria Sebastião, Sandra Henriques Vaz, Sandra Henriques Vaz   +7 more
doaj   +1 more source

Parkinson's disease under dopamine replacement therapy as a human framework for studying addiction‐relevant mechanisms

Psychiatry and Clinical Neurosciences, EarlyView.
Addiction is a chronic relapsing condition characterized by compulsive reward seeking and impaired behavioral control, associated with major individual and societal burden. Mechanistic investigation in humans remains constrained by ethical limitations, uncontrolled exposure histories, and ecological confounds.
Vanessa Fleury, Elvira Pirondini, Damien Benis, Tiffany Corbet, Gabriel Thorens, Christian Lüscher, Paul Krack   +6 more
wiley   +1 more source

Imaging tripartite synapses using super-resolution microscopy

Methods, 2020
Astroglia are vital facilitators of brain development, homeostasis, and metabolic support. In addition, they are also essential to the formation and regulation of synaptic circuits. Due to the extraordinary complex, nanoscopic morphology of astrocytes, the underlying cellular mechanisms have been poorly understood.
Heller, Janosch Peter, Odii, Tuamoru, Zheng, Kaiyu, Rusakov, Dmitri A.   +3 more
openaire   +5 more sources

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source

Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

Alzheimer’s Research & Therapy, 2019
Background The lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with impaired memory and occurs early in the disease process, before the onset of ...
Joshua B. Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Candice C. Askwith, Lin Lin, Michael W. Shultis, Kevin J. Hodgetts, Chien-Liang Glenn Lin   +9 more
doaj   +1 more source

Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
This article provides an overview on model organisms and proposes a new framework for assessing the extent to which it is justified to generalize the results obtained from a given organism. It covers both studies of human diseases and those focused on general biological processes. The first part of the article is a review on model organisms.
Héloïse Athéa, Nicolas Heck
wiley   +1 more source