Results 71 to 80 of about 85,493 (199)

Synapse-level wiring rule inferred with SBI differs from Peters’ rule.

, 2023
We compared an SBI-inferred parametrized wiring rule predicting synapse counts on the subcellular level with a corresponding formulation of Peters’ rule.
Daniel Baum (667717), Daniel Udvary (17027813), Hans-Christian Hege (805638), Jan Boelts (17027804), Richard Gao (17027810), Philipp Harth (17027807), Felipe Yáñez (17027816), Marcel Oberlaender (108892), Jakob H. Macke (4487488)   +8 more
core   +1 more source

Innovative 3D‐bioprinted microfibers in calcium phosphate cement platform with Nell‐1 to activate nerve‐bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration

Smart Molecules, EarlyView.
A 3D‐bioprinted platform with stem cells activates “nerve‐bone” signaling by enabling the spatiotemporal delivery of Nell‐1. This activation enhances neurovascular and bone regeneration through the CYFIP1 cascade. In rat calvarial defects, the platform doubled bone regeneration and nerve repair and tripled vascular density, resulting in superior ...
Minjia Zhu, Xinyi Li, Jingyi Li, Kan Yu, Zixiang Dai, Le Xiao, Qinrou Zhang, Zihan Jia, Qingchen Qiao, Zeqing Zhao, Ke Zhang, Yuxing Bai   +11 more
wiley   +1 more source

Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse

, 2009
The importance of communication between neuronal and glial cells for brain function is recognized by a modern concept of 'tripartite synapse'. Astrocytes enwrap synapses and can modulate their activity by releasing gliotransmitters such as ATP, glutamate
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Andrew, Jemma   +3 more
core   +1 more source

Some Features of Contact Formation between Сhemical Synapse and Astrocytes Membrane in the Primary Somatosensory Сerebral Сortex of Rats

Ветеринарная патология, 2023
Introduction. The contact point between an astrocyte and a chemical synapse is the location of the signaling and transport processes that play an important role in functioning of the nervous system and in neurological diseases pathogenesis of humans and ...
S. Yu. Filippova, E. Yu. Kirichenko, A. K. Logvinov   +2 more
doaj   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

On tripartite common graphs [PDF]

, 2020
A graph H is common if the number of monochromatic copies of H in a 2-edge-colouring of the complete graph is minimised by the random colouring. Burr and Rosta, extending a famous conjecture by Erdos, conjectured that every graph is common.
Lee, Joonkyung, Grzesik, Andrzej, Lidicky, Bernard, Volec, Jan   +3 more
core  

Age-dependent remodelling of ionotropic signalling in cortical astroglia [PDF]

, 2011
Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial.
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Verkhratsky, Alexei, Oleg Palygin, Ulyana Lalo, North, Richard Alan, Richard Alan North, Yuriy Pankratov, North, R. Alan, Verkhratsky, Alexei; id_orcid, Alexei Verkhratsky   +11 more
core   +1 more source

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development [PDF]

, 2022
Neuron-glia interactions play a critical role in the regulation of synapse formation and circuit assembly. Here we demonstrate that canonical Sonic hedgehog (Shh) pathway signaling in cortical astrocytes acts to coordinate layer-specific synaptic ...
Kim, Minsu, Herbert, Zachary T, Sabatini, Bernardo L, Lacey, Tiara E, Adam, Manal, Tolstorukov, Michael Y, Lee, Wei-Chung Allen, Mosto, Olivia, Olukoya, Olubusola, Gómez, Nicolás, Harwell, Corey C, Kuan, Aaron T, Sorour, Ingie, Wang, Wengang, Charpentier, Claire, Xie, Yajun, Vu, Steve, Tran, Diana   +17 more
core   +1 more source

Proof‐of‐concept trial of PP‐01 for mitigating cannabis withdrawal syndrome in participants with cannabis use disorder

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Cannabis withdrawal symptoms can be severe and protracted, significantly impeding the ability to abstain from cannabis use, resulting in failed quit attempts and relapse. This clinical trial evaluated safety and efficacy of PP‐01, a novel dual‑mechanism of action, investigational agent, for mitigating cannabis ...
Ashley F. Slagle, Jay Constantine, Harvey Kushner, Shelli Graham, Ginger Constantine   +4 more
wiley   +1 more source

Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses [PDF]

, 2011
Immune synapses formed by T and NK cells both show segregation of the integrin ICAM1 from other proteins such as CD2 (T cell) or KIR (NK cell).
Dustin, Michael L., van der Merwe P. Anton, Nigel J Burroughs, Michael L Dustin, Van Der Merwe, PA, P Anton van der Merwe, Nigel J. Burroughs, Miloserdov, Vladimir, Van der Merwe, P. Anton, Miloserdov, V, Davis, DM, Dustin, ML, Daniel M Davis, Daniel M. Davis, Davis Daniel M., Köhler, K, Michael L. Dustin, Miloserdov Vladimir, Karsten Köhler, Dustin, Michael, Burroughs Nigel J., Dustin Michael L., Burroughs, Nigel J., P. Anton van der Merwe, Davis, Daniel M., Burroughs, NJ, Köhler Karsten, Van Der Merwe, Philip, Köhler, Karsten, Burroughs, Nigel John, Vladimir Miloserdov   +30 more
core   +1 more source