Results 1 to 10 of about 1,699,867 (343)

Uncoupling Protein 1 Does Not Produce Heat without Activation. [PDF]

Int J Mol Sci, 2022
Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an energy-wasting organ. A constrained strategy that minimizes brown fat activity unless obligate will
Li Y, Fromme T.
europepmc   +6 more sources

Structural basis of purine nucleotide inhibition of human uncoupling protein 1. [PDF]

Sci Adv, 2023
Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial inner membrane, short-circuiting the mitochondrion to generate heat, bypassing ATP synthesis.
Jones SA, Gogoi P, Ruprecht JJ, King MS, Lee Y, Zögg T, Pardon E, Chand D, Steimle S, Copeman DM, Cotrim CA, Steyaert J, Crichton PG, Moiseenkova-Bell V, Kunji ERS.   +14 more
europepmc   +6 more sources

Cell-free production and characterisation of human uncoupling protein 1-3. [PDF]

Biochem Biophys Rep, 2017
The uncoupling proteins (UCPs) leak protons across the inner mitochondrial membrane, thus uncoupling the proton gradient from ATP synthesis. The main known physiological role for this is heat generation by UCP1 in brown adipose tissue. However, UCPs are also believed to be important for protection against reactive oxygen species, fine-tuning of ...
Rebuffet E, Frick A, Järvå M, Törnroth-Horsefield S.   +3 more
europepmc   +6 more sources

Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid Arthritis. [PDF]

Cells, 2021
Adiposity is strongly associated with cardiovascular (CV) morbidity. Uncoupling protein 1 (UCP1) increases energy expenditure in adipocytes and may counteract adiposity. Our objective was to investigate a connection between UCP1 expression and cardiovascular health in patients with rheumatoid arthritis (RA) in a longitudinal observational study ...
Lyngfelt LI, Erlandsson MC, Nadali M, Hedjazifar S, Pullerits R, Andersson KM, Brembeck P, Silfverswärd ST, Smith U, Bokarewa MI.   +9 more
europepmc   +7 more sources

Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity. [PDF]

Mol Metab, 2018
Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition. We measured the cellular concentration and the release of purine
Fromme T, Kleigrewe K, Dunkel A, Retzler A, Li Y, Maurer S, Fischer N, Diezko R, Kanzleiter T, Hirschberg V, Hofmann T, Klingenspor M.   +11 more
europepmc   +8 more sources

Mitochondrial uncoupling protein 1 expression in thymocytes [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out mice. UCP 1 is also shown to be present in thymocytes isolated from rat.
Alison E. Adams, A.M. Carroll, Padraic G. Fallon, Richard K. Porter   +3 more
  +12 more sources

Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1) [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2019
Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these tissues, is the key factor for heat production.
Petr Ježek, Martin Jabůrek, Richard K. Porter   +2 more
openaire   +3 more sources

On the Mechanism of Mitochondrial Uncoupling Protein 1 Function [PDF]

Journal of Biological Chemistry, 2006
Native uncoupling protein 1 (UCP 1) was purified from rat mitochondria by hydroxyapatite chromatography and identified by peptide mass mapping and tandem mass spectrometry. Native and expressed UCP 1 were reconstituted into liposomes, and proton flux through UCP 1 was shown to be fatty acid-dependent and GDP-sensitive.
Eamon P. Breen, Terry W. Pearson, Lee R. Haines, Paul V. Murphy, Andrew Murphy, Sébastien G. Gouin, Richard K. Porter, Angela M. Jackson   +7 more
openaire   +5 more sources

In silico identification of lipid-binding α helices of uncoupling protein 1. [PDF]

Biomed Rep, 2018
Uncoupling protein 1 (UCP1) located at the mitochondrial inner membrane serves an important role in adaptive non-shivering thermogenesis. Previous data has demonstrated that membrane lipids regulate the biological functions of membrane proteins. However, how mitochondrial lipids interact with UCP1 still remains elusive.
Jing Y, Niu Y, Liu C, Zen K, Li D.
europepmc   +5 more sources

Uncoupling Protein 2, but Not Uncoupling Protein 1, Is Expressed in the Female Mouse Reproductive Tract [PDF]

Journal of Biological Chemistry, 2003
Uncoupling proteins (UCPs) are transporters of the inner mitochondrial membrane. Whereas UCP1 is uniquely present in brown adipose tissue where it uncouples respiration from ATP synthesis and activates respiration and heat production, UCP2 is present in numerous tissues, and its exact function remains to be clarified.
Rousset, Sophie, Alves-Guerra, Marie-Clotilde, Ouadghiri-Bencherif, Salma, Kozak, Leslie, Miroux, Bruno, Richard, Denis, Bouillaud, Frédéric, Ricquier, Daniel, Cassard-Doulcier, Anne-Marie   +8 more
openaire   +4 more sources