Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1 [PDF]
Laboratory Animal ResearchBackground Uncoupling protein 1 (UCP1) is a proton uncoupler located across the mitochondrial membrane generally involved in thermogenesis of brown adipose tissues.
Gi-Sue Kang +10 more
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Cell-free production and characterisation of human uncoupling protein 1–3 [PDF]
Biochemistry and Biophysics Reports, 2017 The uncoupling proteins (UCPs) leak protons across the inner mitochondrial membrane, thus uncoupling the proton gradient from ATP synthesis. The main known physiological role for this is heat generation by UCP1 in brown adipose tissue.
Etienne Rebuffet +3 more
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Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides [PDF]
The EMBO JournalUncoupling protein 1 (UCP1, SLC25A7) is responsible for the thermogenic properties of brown adipose tissue. Upon fatty acid activation, UCP1 facilitates proton leakage, dissipating the mitochondrial proton motive force to release energy as heat.
Scott A Jones +9 more
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CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression [PDF]
Antioxidants, 2022 Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditary ...
Ching-Fang Chang +6 more
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Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis [PDF]
Molecular Metabolism, 2022 Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans.
Riccardo Cavalieri +7 more
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Uncoupling protein 1 (UCP1) of brown adipocyte, the only uncoupler: historical perspective [PDF]
Frontiers in Endocrinology, 2011 Uncoupling protein 1 - UCP1, is a unique mitochondrial membranous protein devoted to adaptive thermogenesis, a specialized function operated by the highly specialized oxidative brown adipocytes.
Daniel eRicquier
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Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus [PDF]
Journal of Lipid Research, 1998 Uncoupling protein-1 (UCP-1) activity in brown adipose tissue increases thermogenesis, contributes to facultative energy expenditure in humans, and has been implicated in the pathogenesis of rodent obesity.
Harald Esterbauer +6 more
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Uncoupling Protein 1 Promotes Nile Tilapia Resistance to Acute Cold Stress by Regulating Liver Metabolism [PDF]
MetabolitesBackground: Low temperature stress is a major environmental challenge affecting the growth, metabolism, and survival of many aquaculture species, including Nile tilapia (Oreochromis niloticus).
Meiqing Li +8 more
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FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
Cell Reports, 2015 Fibroblast growth factor 21 (FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in adipose tissues, suggesting that UCP1-dependent thermogenesis may drive FGF21 action.
Michelle M. Kwon +4 more
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Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity [PDF]
Molecular Metabolism, 2018 Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
Tobias Fromme +11 more
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