Results 151 to 160 of about 127,036 (330)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Possibility of uncoupling protein 1 expression in bovine fast-twitch muscle fibers. [PDF]

J Vet Med Sci, 2023
Diao Z, Shimokawa F, Yoshioka H, Itoyama E, Matsumura M, Murakami M, Kitamura S, Nagase H, Matsui T, Funaba M.   +9 more
europepmc   +1 more source

SKELETAL MUSCLE MITOCHONDRIAL OXIDATIVE CAPACITY AND UNCOUPLING PROTEIN 3 ARE DIFFERENTLY INFLUENCED BY SEMISTARVATION AND REFEEDING [PDF]

, 2003
CRESCENZO, RAFFAELLA, DULLOO AG, IOSSA, SUSANNA, LIVERINI, GIOVANNA, MAINIERI D, MONTANI JP, SEYDOUX J, SOLINAS G   +7 more
core   +1 more source

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

Advanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang, Zi‐Han Chen, Jiajia Li, Wei Hu, Ying Cao, Yu Wang, Xiaoyu Tong, Wenhan Lu, Yuze Yang, Yuehao Wang, Yan Xiao, Wenhao Gao, Yuning Chen, Yuyan Hou, Fan Zhang, Yi Feng   +15 more
wiley   +1 more source

Comparison the effect of eight weeks aerobic training with moderate and high intensities on serum levels of Irisin and Uncoupling Protein 1 (UCP-1) in white adipose tissue in obese male rats

مجله دانشگاه علوم پزشکی گرگان, 2018
Background and Objective: The synthesis of uncoupling protein 1 (UCP1) in adipose tissue plays an important role in providing resistance and prevention of fat accumulation, weight gain and obesity.
Keyvan Hejazi, Seyyed Reza Attarzadeh Hosseini, Mehrdad Fathi, Mohammad Mosaferi Ziaaldini, Mahdieh Zaeemi   +4 more
doaj  

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Fasting and Leptin Modulate Adipose and Muscle Uncoupling Protein: Divergent Effects Between Messenger Ribonucleic Acid and Protein Expression¹ [PDF]

, 1999
William I. Sivitz, Brian D. Fink, Patricia A. Donohoue   +2 more
openalex   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a Temperature-Dependent Manner. [PDF]

J Neurosci, 2022
Sideromenos S, Gundacker A, Nikou M, Oberle R, Horvath O, Stoehrmann P, Partonen T, Pollak DD.   +7 more
europepmc   +1 more source

The cJun kinase inhibitor SP600125 stimulates expression of PPARγ co-activator 1α (PGC-1α) and uncoupling protein 1 (UCP1) in the HIB-1B brown fat preadipocyte cell line [PDF]

, 2008
Catherine Wells, Angeliki Karamitri, Georgios Karamanlidis, Michael A. Lomax   +3 more
openalex   +1 more source