Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic protein exclusively expressed in brown adipocytes, the beige adipocytes have a gene expression pattern ...
Okamatsu-Ogura, Yuko +6 more
doaj +7 more sources
FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
Cell Reports, 2015 Fibroblast growth factor 21 (FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in adipose tissues, suggesting that UCP1-dependent thermogenesis may drive FGF21 action. It was reported that FGF21 is equally effective at reducing body weight and improving glucose homeostasis ...
Robert K. Baker +4 more
doaj +6 more sources
Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation. [PDF]
J Obes Metab Syndr, 2018 Background : Uncoupling protein 1 (UCP1) plays an important role in increasing energy expenditure; thus, it is being considered as a new target for preventing obesity and metabolic complications.
Choi H, Kim CS, Yu R.
europepmc +3 more sources
Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress. [PDF]
PLoS One, 2018 Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly ...
Bond LM, Burhans MS, Ntambi JM.
europepmc +3 more sources
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study. [PDF]
BMC Med Genet, 2018 Background Obesity is one of the main causes of morbidity and mortality worldwide. More than 120 genes have been shown to be associated with obesity related phenotypes.
Chathoth S +8 more
europepmc +3 more sources
Uncoupling Protein 1 of Brown Adipocytes, the Only Uncoupler: A Historical Perspective [PDF]
Frontiers in Endocrinology, 2011 Uncoupling protein 1 (UCP1), is a unique mitochondrial membranous protein devoted to adaptive thermogenesis, a specialized function performed by brown adipocytes. Whereas the family of mitochondrial metabolite carriers comprises ∼40 members, UCP1 is the only memberable to translocate protons through the inner membrane of brown adipocyte mitochondria ...
Daniel eRicquier
openaire +5 more sources
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus [PDF]
Journal of Lipid Research, 1998 Uncoupling protein-1 (UCP-1) activity in brown adipose tissue increases thermogenesis, contributes to facultative energy expenditure in humans, and has been implicated in the pathogenesis of rodent obesity. To determine genetic factors controlling UCP-1 expression in humans, we measured intra- and extraperitoneal UCP-1 mRNA abundance levels by a ...
Harald Esterbauer +6 more
openaire +5 more sources
Insulin and the β3-Adrenoceptor Differentially Regulate Uncoupling Protein-1 Expression [PDF]
Molecular Endocrinology, 2000 Cross-talk between insulin and the adrenergic system is important in the regulation of energy homeostasis. In cultured, differentiated mouse brown adipocytes, beta3-adrenergic stimulation induced a 4.5-fold increase in uncoupling protein-1 (UCP-1) expression, which was diminished by 25% in the presence of insulin.
Johannes E. M. N. Klein +4 more
openaire +4 more sources
Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold‐exposed rats [PDF]
FEBS Letters, 2002 Earlier we reported a 14‐fold increase of glycogen in the brown adipose tissue (BAT) in rats when the animals were placed back from cold to neutral temperature. To elucidate the mechanism, here we compared the level of glucose transporter 4 (GLUT4) protein, uncoupling protein (UCP) 1 and UCP3 mRNA and protein expressions in the BAT under the same ...
Peter B. Jakus +3 more
openaire +4 more sources
Test systems to study the structure and function of uncoupling protein 1: a critical overview [PDF]
Frontiers in Endocrinology, 2011 The discovery of active brown adipose tissue (BAT) in healthy adult humans has renewed interest in the biology of this organ. BAT is capable of distributing nutrient energy in the form of heat allowing small mammals to efficiently defend their body ...
Verena eHirschberg +2 more
doaj +2 more sources