Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid Arthritis [PDF]
Cells, 2021 Adiposity is strongly associated with cardiovascular (CV) morbidity. Uncoupling protein 1 (UCP1) increases energy expenditure in adipocytes and may counteract adiposity.
Lovisa I. Lyngfelt +9 more
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Evidence of selection in the uncoupling protein 1 gene region suggests local adaptation to solar irradiance in savannah monkeys (Chlorocebus spp.). [PDF]
Proc Biol Sci, 2022 Gagnon CM +7 more
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Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress. [PDF]
PLoS ONE, 2018 Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly ...
Laura M Bond +2 more
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Neuroprotection and acidosis induced by cortical spreading depression [PDF]
Neuropsychiatric Disease and Treatment, 2016 Kenneth K Kwong, Suk-tak Chan Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA We read with interest the article “Cortical spreading ...
Kwong KK, Chan ST
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Chronic glucocorticoid exposure causes brown adipose tissue whitening, alters whole-body glucose metabolism and increases tissue uncoupling protein-1. [PDF]
Physiol Rep, 2022 Bel JS, Tai TC, Khaper N, Lees SJ.
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Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study [PDF]
BMC Medical Genetics, 2018 Background Obesity is one of the main causes of morbidity and mortality worldwide. More than 120 genes have been shown to be associated with obesity related phenotypes.
Shahanas Chathoth +8 more
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Uncoupling protein 1 knockout aggravates isoproterenol-induced acute myocardial ischemia via AMPK/mTOR/PPARα pathways in rats. [PDF]
Transgenic Res, 2022 Hou D +7 more
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Uncoupling protein 1 inhibits mitochondrial reactive oxygen species generation and alleviates acute kidney injury [PDF]
EBioMedicine, 2019 Background: Uncoupling protein 1 (UCP1) is predominantly found in brown adipose tissue mitochondria, and mediates energy dissipation to generate heat rather than ATP via functional mitochondrial uncoupling.
Ping Jia +5 more
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Uncoupling Protein 1 Does Not Produce Heat without Activation. [PDF]
Int J Mol Sci, 2022 Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown fat, ultimately, is an energy-wasting organ. A constrained strategy that minimizes brown fat activity unless obligate will
Li Y, Fromme T.
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Uncoupling Protein 2, but Not Uncoupling Protein 1, Is Expressed in the Female Mouse Reproductive Tract [PDF]
Journal of Biological Chemistry, 2003 Uncoupling proteins (UCPs) are transporters of the inner mitochondrial membrane. Whereas UCP1 is uniquely present in brown adipose tissue where it uncouples respiration from ATP synthesis and activates respiration and heat production, UCP2 is present in numerous tissues, and its exact function remains to be clarified.
Sophie Rousset +8 more
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