Results 21 to 30 of about 127,036 (330)

Localization of uncoupling protein 1 (UCP-1) in the sebaceous gland of the dorsal region in the Sunda porcupine (Hystrix javanica). [PDF]

J Vet Med Sci, 2020
Prawira AY, Novelina S, Farida WR, Darusman HS, Warita K, Agungpriyono S, Hosaka YZ.   +6 more
europepmc   +3 more sources

Relationship between uncoupling protein 1 (UCP1) levels and psoriasis. [PDF]

Turk J Med Sci
Psoriasis is a common chronic autoimmune skin disease. Comorbidities increase the mortality risk of the disease. The aim of this study was to investigate the changes in uncoupling protein 1 (UCP1) level in psoriasis patients and evaluate its possible role in the pathogenesis of the disease, focusing on disease severity (Psoriasis Area and Severity ...
Akyürek F, Tuncez Akyürek F, Şengül Bağ F.   +2 more
europepmc   +3 more sources

Mitochondrial uncoupling protein 1 expression in thymocytes [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out mice. UCP 1 is also shown to be present in thymocytes isolated from rat.
Adams, Alison E., Carroll, Audrey M., Fallon, Padraic G., Porter, Richard K.   +3 more
openaire   +7 more sources

Structural basis of purine nucleotide inhibition of human uncoupling protein 1. [PDF]

Sci Adv, 2023
Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial inner membrane, short-circuiting the mitochondrion to generate heat, bypassing ATP synthesis.
Jones SA, Gogoi P, Ruprecht JJ, King MS, Lee Y, Zögg T, Pardon E, Chand D, Steimle S, Copeman DM, Cotrim CA, Steyaert J, Crichton PG, Moiseenkova-Bell V, Kunji ERS.   +14 more
europepmc   +6 more sources

SAT-255 Evaluation of Uncoupling Protein 1 and Fibroblast Growth Factor 21 in Obese Adolescents

J Endocr Soc, 2019
Pamuk G, Ozturk Z, Alikasifoglu M, Erginoz E, Ercan O.   +4 more
europepmc   +2 more sources

Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1) [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2019
Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these tissues, is the key factor for heat production.
Petr, Ježek, Martin, Jabůrek, Richard K, Porter   +2 more
openaire   +2 more sources

Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis [PDF]

Trends in Biochemical Sciences
In mitochondria, the oxidation of nutrients is coupled to ATP synthesis by the generation of a protonmotive force across the mitochondrial inner membrane. In mammalian brown adipose tissue (BAT), uncoupling protein 1 (UCP1, SLC25A7), a member of the SLC25 mitochondrial carrier family, dissipates the protonmotive force by facilitating the return of ...
Scott A. Jones, Jonathan J. Ruprecht, Paul G. Crichton, Edmund R.S. Kunji   +3 more
openalex   +5 more sources

Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]

PLoS ONE, 2013
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura, Keigo Fukano, Ayumi Tsubota, Akihiro Uozumi, Akira Terao, Kazuhiro Kimura, Masayuki Saito   +6 more
doaj   +1 more source

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Redox Biology, 2023
Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health.
Jinit Masania, Patrick Wijten, Susanne Keipert, Mario Ost, Susanne Klaus, Naila Rabbani, Paul J. Thornalley   +6 more
doaj   +1 more source

Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling

Cell Calcium, 2023
Mitochondrial uncoupling proteins UCP1 and UCP2 have a structural homology of app. 60%. They execute their mitochondria uncoupling function through different molecular mechanisms. Non-shivering thermogenesis by UCP1 is mediated through a transmembrane dissipation of the proton motive force to create heat during sympathetic stimulation.
Furkan E. Oflaz, Zhanat Koshenov, Martin Hirtl, Olaf A. Bachkoenig, Wolfgang F. Graier, Benjamin Gottschalk   +5 more
openaire   +2 more sources