Results 21 to 30 of about 1,699,867 (343)

Uncoupling protein 1 inhibits mitochondrial reactive oxygen species generation and alleviates acute kidney injury. [PDF]

EBioMedicine, 2019
Background: Uncoupling protein 1 (UCP1) is predominantly found in brown adipose tissue mitochondria, and mediates energy dissipation to generate heat rather than ATP via functional mitochondrial uncoupling.
Jia P, Wu X, Pan T, Xu S, Hu J, Ding X.
europepmc   +3 more sources

Transcriptional regulation of the uncoupling protein-1 gene

Biochimie, 2017
Regulated transcription of the uncoupling protein-1 (UCP1) gene, and subsequent UCP1 protein synthesis, is a hallmark of the acquisition of the differentiated, thermogenically competent status of brown and beige/brite adipocytes, as well as of the responsiveness of brown and beige/brite adipocytes to adaptive regulation of thermogenic activity.
Marta Giralt, Marion Peyrou, Francesc Villarroya   +2 more
openaire   +4 more sources

Uncoupling protein-1 is not leaky

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
The activity of uncoupling protein-1 (UCP1) is rate-limiting for nonshivering thermogenesis and diet-induced thermogenesis. Characteristically, this activity is inhibited by GDP experimentally and presumably mainly by cytosolic ATP within brown-fat cells.
Marek Vrbacky, Mario Ost, Jan Nedergaard, Irina G. Shabalina, Barbara Cannon, Natasa Petrovic   +5 more
openaire   +4 more sources

Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria [PDF]

Biochemical Journal, 2004
Q (coenzyme Q or ubiquinone) is reported to be a cofactor obligatory for proton transport by UCPs (uncoupling proteins) in liposomes [Echtay, Winkler and Klingenberg (2000) Nature (London) 408, 609–613] and for increasing the binding of the activator retinoic acid to UCP1 [Tomás, Ledesma and Rial (2002) FEBS Lett. 526, 63–65].
Martin D. Brand, Catherine F. Clarke, Tanya Jonassen, Karim S. Echtay, Telma C. Esteves   +4 more
openaire   +4 more sources

Milk Fat Globule Membrane Attenuates High-Fat Diet-Induced Obesity by Inhibiting Adipogenesis and Increasing Uncoupling Protein 1 Expression in White Adipose Tissue of Mice [PDF]

Nutrients, 2018
Milk fat globule membrane (MFGM), a protein-lipid complex surrounding the fat globules in milk, has many health benefits. The aim of the current study was to investigate whether MFGM could prevent obesity through inhibiting adipogenesis and promoting ...
Tiange Li, Jing Gao, M. Du, Jiajia Song, X. Mao   +4 more
semanticscholar   +2 more sources

CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression. [PDF]

Antioxidants (Basel), 2022
Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditary ...
Chang CF, Gunawan AL, Liparulo I, Zushin PH, Bertholet AM, Kirichok Y, Stahl A.   +6 more
europepmc   +2 more sources

Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1β production. [PDF]

Sci Adv, 2021
The mitochondrial protein UCP1 has potent therapeutic effects on vascular inflammation and atherosclerosis.
Gu P, Hui X, Zheng Q, Gao Y, Jin L, Jiang W, Zhou C, Liu T, Huang Y, Liu Q, Nie T, Wang Y, Wang Y, Zhao J, Xu A.   +14 more
europepmc   +2 more sources

Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue [PDF]

International Journal on Biological Sciences, 2012
Liver X receptors (LXRs) play important roles in regulating cholesterol homeostasis, and lipid and energy metabolism. Therefore, LXR ligands could be used for the management of metabolic disorders.
X. Sheng, Xuehua Zhu, Yuebo Zhang, Guoliang Cui, Linling Peng, Xiong Lu, Y. Zang   +6 more
semanticscholar   +2 more sources

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis. [PDF]

Mol Metab, 2022
Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans.
Cavalieri R, Hazebroek MK, Cotrim CA, Lee Y, Kunji ERS, Jastroch M, Keipert S, Crichton PG.   +7 more
europepmc   +2 more sources

Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1. [PDF]

Lab Anim Res
Background Uncoupling protein 1 (UCP1) is a proton uncoupler located across the mitochondrial membrane generally involved in thermogenesis of brown adipose tissues.
Kang GS, Kim YE, Oh HR, Jo HJ, Bok S, Jeon YK, Cheon GJ, Roh TY, Chang YT, Park DJ, Ahn GO.   +10 more
europepmc   +2 more sources