Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1. [PDF]
Mol Nutr Food Res, 2019 SCOPE Brown adipose tissue (BAT) dissipates energy through uncoupling protein 1 (UCP1) and has been proposed as an anti-obesity target. It was reported previously that a high-fat (HF) diet enriched in eicosapentaenoic acid (EPA) significantly increased ...
Pahlavani M +7 more
europepmc +2 more sources
Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation. [PDF]
Life Sci Alliance, 2018 Quantification of substrate fluxes in brown adipocytes clarifies contributors to extracellular acidification, identifies a futile cycle of lipolysis and re-esterification, and suggests a role for glycogen during activation.
Schweizer S +3 more
europepmc +2 more sources
Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. [PDF]
Sci Rep, 2019 The number of brown adipocytes residing within murine white fat depots (brite adipocytes) varies a lot by depot, strain and physiological condition. Several endocrine fibroblast growth factors are implicated in the regulation of brite adipocyte abundance.
Westphal S +5 more
europepmc +2 more sources
Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases [PDF]
, 2017 Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative ...
Forte, Maurizio +6 more
core +5 more sources
Mitochondrial Brown Fat Uncoupling Protein 1
Definitions, 2020 Mitochondrial brown fat uncoupling protein 1 (307 aa, ~33 kDa) is encoded by the UCP1 gene.
semanticscholar +1 more source
H+ transport is an integral function of the mitochondrial ADP/ATP carrier. [PDF]
, 2019 The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP.
Angelin, Alessia +12 more
core +1 more source
Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4. [PDF]
, 2017 Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through
Chawla, Ajay +6 more
core +1 more source
Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo
Pharmaceuticals, 2022 Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ...
Attila Vámos +9 more
doaj +1 more source
Neuroprotection and acidosis induced by cortical spreading depression [PDF]
, 2016 We read with interest the article “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5” published in Neuropsychiatr Dis Treat by Viggiano et al.1 The authors showed that cerebral spreading ...
Chan, Suk-tak, Kwong, Kenneth K
core +1 more source
Cell Calcium, 2023 Mitochondrial uncoupling proteins UCP1 and UCP2 have a structural homology of app. 60%. They execute their mitochondria uncoupling function through different molecular mechanisms. Non-shivering thermogenesis by UCP1 is mediated through a transmembrane dissipation of the proton motive force to create heat during sympathetic stimulation.
Furkan E. Oflaz +5 more
openaire +2 more sources