Results 41 to 50 of about 1,699,867 (343)

Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. [PDF]

PLoS ONE, 2009
BACKGROUND:Increasing energy expenditure at the cellular level offers an attractive option to limit adiposity and improve whole body energy balance. In vivo and in vitro observations have correlated mitochondrial uncoupling protein-1 (UCP1) expression ...
Yaguang Si, Hai Shi, Kyongbum Lee
doaj   +1 more source

Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20
Stephen B. Smith, Craig R. Sweatt, Gordon E. Carstens   +2 more
doaj   +1 more source

P38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity [PDF]

, 2014
Background Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease.
Ming, Xiu-Fen, Montani, Jean-Pierre, Rajapakse, Angana G., Yang, Zhihong, Yu, Yi   +4 more
core   +2 more sources

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Cells, 2019
Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis.
Stéphane Demine, Patricia Renard, Thierry Arnould   +2 more
doaj   +1 more source

Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system.

American Journal of Physiology. Endocrinology and Metabolism, 2019
Uncoupling protein 1 provides non-shivering thermogenesis fueled by the dissipation of energy from macronutrients in brown and brite adipocytes. The availability of thermogenic fuels is facilitated by the uptake of extracellular glucose. This conjunction
Stefanie Maurer, T. Fromme, Sabine Mocek, Anika Zimmermann, M. Klingenspor   +4 more
semanticscholar   +1 more source

Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress [PDF]

, 2013
Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction.
Berkowitz, DE, Bivalacqua, TJ, Burnett, AL, Champion, HC, Hsu, LL, Musicki, B   +5 more
core   +6 more sources

Expression of uncoupling proteins-1,-2 and-3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor [PDF]

, 2002
The abnormalities of lipid metabolism observed in cancer cachexia may be induced by a lipid-mobilizing factor produced by adenocarcinomas. The specific molecules and metabolic pathways that mediate the actions of lipid-mobilizing factor are not known ...
A Negre-Salvayre, A Rashid, C Bing, C Bing, C Bing, C Bing, C Fleury, CS Hwang, D Arsenijevic, D Ricquier, DS Weigle, E E Beckett, E Nisoli, FY Lee, G Williams, H Cortez-Pinto, J Matsuda, J Nedergaard, JC Clapham, JH Shaw, JM Reilly, K Hirai, L Millet, M J Tisdale, M Puccio, O Boss, O Boss, O Boss, O Champigny, P Barbe, P Collins, P Groundwater, P Trayhurn, P Trayhurn, P Trayhurn, PT Todorov, R Barraclough, RE Gimeno, S Bao, S Samec, S Samec, S T Russell, S Taylor, SB Prusiner, SL Taylor, WI Sivitz, Y Khalfallah   +46 more
core   +2 more sources

Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes

International Journal of Molecular Sciences, 2019
Endoplasmic reticulum (ER) homeostasis is critical in maintaining metabolic regulation. Once it is disrupted due to accumulated unfolded proteins, ER homeostasis is restored via activation of the unfolded protein response (UPR); hence, the UPR affects ...
Ana Yuliana, Asumi Daijo, Huei-Fen Jheng, Jungin Kwon, W. Nomura, Haruya Takahashi, T. Ara, T. Kawada, T. Goto   +8 more
semanticscholar   +1 more source

Electrophysiological Characterization of Mitochondrial Uncoupling Protein 1

Biophysical Journal, 2009
Uncoupling proteins (UCP1- UCP5) are integral transport proteins of the inner mitochondrial membrane (IMM). They mediate transmembrane ion leak, thus dissipating the electrochemical proton gradient across the IMM and uncoupling mitochondrial respiration and ATP synthesis.
Polina V. Lishko, Andriy Fedorenko, Yuriy Kirichok   +2 more
openaire   +2 more sources

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat [PDF]

, 2017
UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP.
Baima, Simona, Bianchi, Franca, Cotugno, Maria, D'Esposito, Maurizio, Fioriniello, Salvatore, Forte, Maurizio, Gelosa, Paolo, Madonna, Michele, Marchitti, Simona, Morelli, Giorgio, Ragione, Floriana Della, Rubattu, Speranza Donatella, Sciarretta, Sebastiano, Sironi, Luigi, Stanzione, Rosita, Volpe, Massimo   +15 more
core   +1 more source